Description
Nanosensors in Healthcare Diagnostics examines the role of nanosensors in clinical microbiology, point-of-care sensing, clinical diagnostics, and therapy.This book addresses the concept of nanosensors and their utilization in healthcare diagnostics, and therapy. It covers the principles and mechanisms involved in nanosensor-based diagnostics platforms. It also discusses various approaches and techniques used in the preparation of nanosensors as well as the biomedical application of nanosensors in clinical diagnostics and their significance in the detection, treatment, and management of diseases. This book is a useful reference for researchers, graduate students, and industry professionals studying nanosensors in biological and medical sciences.• Brings together multiple perspectives, in-depth analyses, and insights on nanosensors and its application in disease diagnostics and therapy• Covers the basic aspects of functioning principles and discusses the technologies and challenges of present and future analytical sensing approaches for diagnosis and treatment• Outlines the significant types of nanosensor platforms explored and developed for efficient detection
Table of Contents
List of contributors About the editorsForewordPrefaceCHAPTER 1 Nanobiosensors for point-of-care diagnostic applicationsNamrata Sangwan, Radhika Dhawan, Arushi Chauhan, Jitender Singh and Pramod K. Avti1.1 Introduction1.2 Diagnostic biological markers 1.2.1 Protein biological markers1.2.2 Metabolites biological markers1.2.3 Nucleic acid biological markers1.2.4 Pathogenic biological markers1.3 Diagnostic role of nanobiosensors in biomedical field1.3.1 Noncommunicable diseases1.3.2 Communicable diseases1.4 Summary and future perspectiveReferencesCHAPTER 2 Gold-conjugated polymeric nanoparticles as biosensorsSarin Palakkal2.1 Introduction2.1.1 Gold nanoparticle-based piezoelectric biosensors2.2 Biosensor's state of the art2.2.1 Gold nanoparticles sensing by fluorescence quenching2.2.2 Gold nanoparticles surface plasmon resonance-based sensors2.2.3 Detection of metal ions2.3 Detection of small organic molecules and protein2.4 ConclusionsReferencesCHAPTER 3 Biosensors for detection of Alzheimer's disease: a reviewManju Tewari3.1 Introduction3.1.1 Neurodegenerative diseases3.1.2 Alzheimer's disease and its diagnosis3.2 Biomarkers of Alzheimer's disease3.2.1 Amyloid beta proteins3.2.2 Tau protein3.2.3 Apolipoprotein E43.3 Biosensors3.3.1 Bioreceptors3.3.2 Transducers3.3.3 Signal amplification3.4 ConclusionAcknowledgmentsConflict of interestReferencesCHAPTER 4 Nanodrug delivery—a noble approach in neurodegenerative disorder and glioblastomaKumudesh Mishra and Or Kakhlon4.1 Introduction4.2 Neurological diseases and treatment strategies4.2.1 Neurodegenerative disease4.3 The bloodbrain barrier and nanotechnology4.4 Bloodbrain barrier crossing mechanism by nanomaterial4.5 Nanocarriers in drug delivery4.5.1 Inorganic nanocarriers for drug delivery4.5.2 Organic nanocarriers4.6 Recent advancements in nano-based treatment of brain disorders4.6.1 Scaffold4.6.2 Three- and four-dimensional printing4.6.3 Induced pluripotent stem cells4.6.4 Nanocarrier-based gene therapy4.7 Clinical trials and current status of nanomedicines in the treatment of neurodegenerative diseases4.8 Challenges and approaches to overcome barriers in the nano-based treatment of neurodegenerative diseases and glioblastoma multiforme4.9 Conclusion and future perspectiveReferencesCHAPTER 5 Advancements in nanosensors for an early detection of cancerAshmit Verma, Payal Kumar, Muzammil Kuddushi, Gayatri Joshi, Saumyakanti Khatua, Mukesh Dhanka and Deepak S. Chauhan5.1 Introduction5.2 Classification of nanosensors5.2.1 Based on the materials used5.2.2 Based on the mode of transduction5.3 Role of nanosensors in an early detection of cancer5.3.1 Detection of biomarkers5.3.2 Detection of circulating tumor cells and exosomes5.3.3 Probing of living cancer cells5.3.4 Bioimaging of tumors5.3.5 Artificial intelligence with nanosensors for bioimaging5.3.6 Micro- and nanorobotics for an early detection of cancer5.3.7 ConclusionAcknowledgmentsReferencesCHAPTER 6 Biomedical applications of nanobiosensors in cancer—recent advances and future prospectsRajalakshmi Manikkam, Periyasamy Vijayalakshmi, Sabapathy Indu and Balakrishnan Solaimuthu6.1 Introduction6.1.1 Cancer onset and types6.2 Cancer diagnostic tools6.3 Nanotechnology6.3.1 Classification of nanoparticles6.3.2 Nanoparticles in biomedical applications6.4 Nanomaterials as biosensors—a novel approach to cancer diagnostics6.5 Cancer biomarkers6.5.1 Detection method6.6 Nanobiosensors6.7 Clinical trial of biosensors6.8 Advantages of nanobiosensors6.9 ConclusionReferencesCHAPTER 7 Nanomaterial-based nanosensors for food safety applicationsArushi Chauhan, Namrata Sangwan, Radhika Dhawan, Jitender Singh and Pramod K. Avti7.1 Introduction7.2 Food safety and nanosensors7.3 Types of nanosensors7.3.1 Optical sensors7.3.2 Piezoelectric sensors7.4 Application in healthcare trends7.4.1 Food processing7.4.2 Nutraceuticals delivery and food packaging7.4.3 Food safety7.
