Description
Understanding the Pandemic: Pathophysiology, Transmission, and Treatment of COVID-19 aims to cover all aspects of COVID-19 infection from the virus, transmission, pathogenesis, immune-inflammation response, systemic injury, organ damage and associated factors comorbidities that drive mortality. Treatment protocols and the vaccination paradigm will also be discussed.Organized into ten sections, the book aims to provide a comprehensive examination of the impact of COVID-19. The book begins a review of coronaviruses, their structure and mechanism of action. The book goes on to discuss the immune response to the virus and its effect on various organs. It examines clinical cases based on an observations and postmortem studies. Other topics include the long-term effects of COVD-19, vaccines, and public health response.• Discusses coronavirus, their similarities and differences in origin and transmission as well as a review of their structure and mechanisms of action• Examines the immune-inflammation responses to COVID-19 and the organ-specific impact of the disease• Covers vaccines and other treatment protocols and public health responses in various geographic locations
Table of Contents
Section 1: Coronaviruses (including SARS 1 and MERS), the Structure (sequence), Mechanism of ActionIntroduction1. Origin, Evolution and Spread of SARS-CoV-22. SARS-CoV-2 Spike Proteins in Infectivity 3. Structural and functional properties of the SARS-CoV-2 spike protein: potential vaccine and drug development for COVID-194. Population-Specific Polymorphisms and SARS-CoV-2 Infectivity5. Insights into SARS-CoV-2 Structure: Approaches and Action of SARS-CoV-2 Main Protease Inhibitors6. SARS-CoV-2, SARS-CoV, and MERS-COV: Similarities and Differences in Origin and TransmissionSection 2: Inflammation and Immune Response to SARS-CoV-2Introduction7. Characterization of the Immune Response with Viral Attack8. Inflammation, Cytokines and COVID-19 Severity9. Immunological Considerations for COVID-19: Vaccines and Other Protective Strategies10. Virus-specific T cell response in SARS-CoV-2 infection and vaccinations11. Oral and Gut Inflammation and Microbiota with COVID-19 12. Implications of Inflammation: Bone and Joint Health with COVID-1913. COVID-19 and immune dysfunction: Consequences, and natural remedies for managementSection 3: Pathological Findings with Clinical CorrelationIntroduction14. Pulmonary Pathology of Severe Covid-1915. Histopathological Analysis of the Cardiovascular System in severe COVID-1916. Postmortem Neuropathology in COVID-1917. Renal Pathology in Severe Covid-19Section 4: The Blood Vessels and COVID-19: Vascular Dysfunction and CoagulopathiesIntroduction18. Vascular Manifestations of COVID-19: Endothelial Dysfunction and Damage19. Immunothrombosis involvement in COVID-1920. COVID-19 associated coagulopathy21. D-dimer in systemic circulation and COVID-19 outcome22. Hypercoagulability in COVID-19Section 5: Neuro-COVID-19 and its Long-Term ImplicationsIntroduction23. COVID and the Nervous System: Mechanisms and Consequences24. Neuroinflammation: Unraveling Acute and Long COVID-19 Effects25. Acute and Post-acute Neurologic and Psychiatric Manifestations in COVID-1926. Pediatric Neurological and Neuropsychiatric Manifestations of COVID-1927. Understanding the Pandemic: Pathophysiology, Transmission, and Treatment of Covid-19Section 6: Should Covid-19 Concern Nephrologists? Why and to What Extent?"Introduction28. Acute Kidney Injury with COvid-19: Mechanisms, Management, and Long-term Outcomes29. Models and Cellular Monolayers to Study the Effect of SARS-CoV-2 on Kidneys30. Clinical implications of COVID-19 in chronic kidney disease and end-stage kidney diseaseSection 7: Long COVID-19 (long term effects - summarizing of clinical reports in literature) Introduction31. Long COVID or Post-Acute Sequalae of COVID: An introduction32. Long COVID: Pathophysiology and classification33. Gender differences in Sequelae from COVID-19 Infection34. Characterizing Long COVID-19: Lessons in the Clinic.35. Implications of Long COVID for the Global Health Care SystemSection 8: The Vaccines Introduction36. COVID-19: The Vaccine Development Strategies37. mRNA vaccines: The New Frontier38. Covid-19 vaccines: A Comprehensive review of Safety and EfficacySection 9: Handling the Spread: Public Health and Social MeasuresIntroduction39. Lockdown measures during the COVID-19 pandemic40. Efficacy of Facial masks against COVID-1941. Vaccination Policies42. Navigating the Impact of COVID-19 School Closures on Child Health, Education, and Society: A Call to Embrace Civil Discourse Across Identities, Sectors, and Disciplines43. The Effect of the Pandemic on Care for Other Health Conditions44. The role of smartphone-assisted tools for Covid-19 diagnostic, treatment, and quarantineSection 10: From the Editors' desk 45. What have we learnt from the COVID-19 pandemic?
