Description
TRP Channels as Therapeutic Targets, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. The Editor lined up a team of worldwide experts in academia and corporate R&D to provide diverse views into these promising drug development targets.Following the research development happened in the past ten years, since the first edition published, the revision includes seven new chapters. All remaining chapters are completely updated. New topics included in the book are TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation.TRP Channels as Therapeutic Targets, Second Edition is a reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline, will find in this book their biologic principles of action.- Presents the perspectives of several life science research specialties on the topic- Provides a comprehensive picture of the TRP field, from TRP channel dysfunction through TRP drug discovery and development to clinical trials and everyday medical practice- Represents an updated and complete reference
Table of Contents
1. A brief introduction to trp channel biology2. The crystal structure of trp channels: implications for drug discovery3. TRP channel dysfunction in hereditary diseases ("TRP channelopathies")4. Altered trp channel expression in acquired disease5. TRP gene polymorphism and disease risk6. Targeting trpv1 channels for pain relief7. Trpa1 antagonists for pain relief8. TRP channels and migraine9. Emerging pain targets: trpm and trpc channels10. Trp channels in bladder disorders11. TRP channels in respiratory diseases12. TRP channels: emerging targets in covid and its complications13. TRP channels and cerebrovascular diseases14. Targeting TRP channels for relief from itch15. TRP channels in dermatological disorders16. TRP channels in hypertension17. TRP channels in diabetes, obesity, and metabolic syndrome18. TRP channels cardiovascular disease19. TRP channels and digestive disease20. TRP channels and cancer21. TRP channels for anxiety relief and for improving mental health22. TRP channels and neurodegenerative disorders23. Mucolipidosis24. TRP channels and renal disease25. TRP channels and arthritis26. TRP channels and thermoregulation: therapeutic opportunities
