Description
Intense immunosuppression followed by Hematopoietic Stem Cell Transplantation for Neurological Diseases (HSCT) has been evaluated as a possible therapeutic tool in severe autoimmune diseases for the last 20 years. In the neurological field, HSCT has been widely investigated for the treatment of multiple sclerosis and evidence is accumulating about its potential use in neuromyelitis optica, stiff person syndrome, myasthenia gravis and many immune neuropathies. This volume summarizes that research. Besides their strong clinical relevance, studies on HSCT in neurological diseases have contributed to mew insights on the pathological mechanisms underlying CNS autoimmunity.- Reviews immunological mechanisms of HSCT and CNS autoimmunity- Identifies neurological diseases showing treatment efficacy with HSCT- Includes MS, myasthenia gravis, neuromyelitis optica, and more- Covers early and late side effects of HSCT
Table of Contents
1. Introduction to HSCT for neurologic diseases2. Modification of T and B cell-associated immuno-pathological mechanisms in multiple sclerosis by disease modifying therapies: achievements and opportunities3. The hematopoietic niche and the autoreactive memory in autoimmune disorders4. The preclinical data and immunological rationale for hematopoietic stem cell transplantation in autoimmunity5. Immune cell reconstitution following autologous hematopoietic stem cell transplantation in multiple sclerosis6. Immune reconstitution in rheumatic disease patients after autologous hematopoietic stem cell transplantation7. The role of chemotherapy in hematopoietic stem cell transplantation HSCT for autoimmune disorders: from lymphoablative to myeloablative conditioning protocols8. The HSCT procedure (I): mobilization, collection, manipulation and cryopreservation of HSC9. The HSCT procedure (II): conditioning, hemopoietic stem cell infusion, supportive care and monitoring10. Early and late complications of HSCT11. Hematopoietic Stem Cell Transplantation for Multiple Sclerosis12. Hematopoietic stem cell transplantation for neuromyelitis optica spectrum disorder. Can immune tolerance be re-established?13. Hematopoietic stem cell transplantation (HSCT) for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): Is it CIDP?14. HSCT for Stiff Person Syndrome and Myasthenia Gravis15. Autologous hematopoietic stem cell transplantation for pediatric autoimmune neurologic disorders16. HSCT for systemic autoimmune diseases with neurologic involvement17. Hematopoetic Stem Cell Therapy and Ex Vivo Gene Therapy for X-linked Adrenoleukodystrophy18. Economics of Hematopoietic Stem Cell Transplant in immune-mediated neurologic autoimmune diseases19. The EBMT-ADWP and the CIBMTR20. Ongoing randomized clinical trials on HSCT in multiple sclerosis
