Description
**Selected for 2025 Doody's Core Titles® with "Essential Purchase" designation in Allergy/Clinical Immunology**The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the "3 P's" of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients.This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field.- Provides new research on autoimmune diseases, their diagnosis, prevention, and therapy- Covers a complete range of all common, rare and new autoimmune diseases, including cancer and COVID- Extensively revised with 75% new material based on autoimmunity, developments in the different diagnosis and therapies for these autoimmune diseases, and a completely updated description of the different diseases- Supplemented with a website that hosts a Podcast per chapter
Table of Contents
Section 1: Immunologic Basis of Autoimmunity1. Prelude: Historical introduction to autoimmunity and autoimmune disease2. Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity3. General Features of Autoimmune Diseases (same title new contributor, new content)4. Antigen Presentation, Dendritic Cells, and Autoimmunity5. T cells and their subsets6. Role of Th1 Th2 Th17 Cells in Autoimmunity7. Tolerance and Autoimmunity: T Cells8. Regulatory T Cells9. B Cells and Autoimmunity10. Immunological memory T cells11. Immunological memory B cells12. Apoptotic Cells as a Source of Autoantigens13. Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes14. Functional Effects of Autoantibodies15. Cytokine, Chemokines 16. Signaling Pathways in T and B Lymphocytes17. HLA Genetics and Autoimmunity18. Non HLA Genetics19. AIRE related Autoimmunity20. Immune Deficiencies and Autoimmunity21. Infections and Autoimmunity22. Noninfectious Environmental Agents and Autoimmunity23. Sex, Pregnancy and Autoimmunity24. Animal Models of Autoimmune DiseaseSection 2: Multisystem Diseases25. Systemic Lupus Erythematosus26. Systemic Sclerosis, Scleroderma27. Antiphospholipid Syndrom28. Sjogren Syndrome29. Rheumatoid Arthritis30. Spondyloarthritis and Chronic Idiopathic Arthropathies31. Myositis32. Thyroid Disease33. Type 1 Diabetes34. Adrenalitis35. Polyendocrine Syndromes36. Gastritis and Pernicious Anemia37. Hypophysitis38. Hemolytic Anemia39. Thrombocytopenic Purpura40. Neutropenia41. Aplastic Anemia42. Clotting Disorders43. Multiple Sclerosis44. Peripheral Neuropathy45. Myasthenia Gravis46. Ocular Disease47. Inner Ear Disease48. Celiac Disease49. Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn's Disease50. Chronic Hepatitis51. Primary Billiary Cirrhosis52. Primary Sclerosing Cholangitis53. Pancreatitis54. Bullous Skin Diseases: Pemphigus and Pemphigoid55. Non-Bullous Skin Diseases: Alopecia, Vitiligo, Psoriasis and Urticaria56. Kidney Disease: Goodpasture's Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis57. Orchitis and Male Infertility58. Oophoritis59. Rheumatic Heart Disease60. Myocarditis and Dilated Cardiomyopathy61. Necrotizing Arteritis and Small Vessel Vasculitis62. Large and Medium Vessel Vasculitides63. Autoimmune Disorders of the Lung64. Paraneoplastic Diseases65. Antibody-Associated Neurological Diseases66. Autoinflammatory and other Related Diseases67. Autoinflammatory diseases and autoimmune responses to tumors68. COVIDSection 3: Diagnosis, Prevention, and Therapy69. Autoantibody Assays, Testing, and Standardization70. Prediction of Autoimmune Disease71. Emerging Therapies for Autoimmune Diseases72. Postlude
