Description
Early diagnosis of HNSCC can cause improved treatment, treatment response rates and reduction in mortality rates. Recently, miRNA-based diagnostics and therapeutics have gained considerable attention among the scientific community. MiRNAs are known to have great potential as biomarkers for early diagnosis, prediction, and prognosis of HNSCC, and play a role in development of targeted gene therapy.Diagnostic, Prognostic and Therapeutic Role of MicroRNAs in Head and Neck Cancer provides detailed information on various miRNA-based approaches for diagnosis, prognosis, and treatment of HNSCC. It encompasses various miRNA-based point of care diagnostics and drug delivery systems for HNSCC along with the information on the clinical trials of miRNAs for improved clinical outcomes in HNSCC patients. The book provides a comprehensive overview of currently available miRNAs associated with HNSCC and their extensive application for early diagnosis, prognosis, and treatment. This book will help scientists and clinicians to win the battle against HNSCC.- Covers the role of the tumor microenvironment in head and neck cancer- Provides information on oncogenic and tumor suppressor miRNAs dysregulated in HNSCC patients- Elucidates the role of miRNAs in metastasis, recurrence, and chemoresistance in HNSCC- Includes the current state-of-art in miRNA-based clinical trials for head
Table of Contents
1. Epidemiology, pathology and genomic topography of head and neck cancer2. Association of human papillomavirus with head and neck cancer3. microRNA regulation of different subtypes of head and neck cancer4. Oncogenic and tumor suppressor microRNAs in head and neck cancer5. Epigenetic regulation of head and neck cancer by microRNAs6. Association of genetic variations in microRNAs with susceptibility to head and neck cancer7. Role of microRNAs in metastasis, recurrence and chemo-radiation resistance of head and neck cancer8. Regulation of head and neck tumor microenvironment by microRNAs9. Genome wide discovery and prediction of microRNA-based biomarkers in head and neck squamous cell carcinoma10. Computational modelling for identification of miRNAs as diagnostic and prognostic biomarkers for head and neck cancer11. Development of microRNA as diagnostic markers in head and neck cancer12. Development of microRNA as prognostic markers in head and neck cancer13. Exosomal microRNA for diagnosis and prognosis of head and neck cance14. MicroRNA expression profiling for disease progression assessment15. MicroRNA-based point-of-care devices for diagnosis and prognosis of head and neck cancer16. Therapeutic role of microRNAs in management of head and neck cancer17. miRNAs in the management of nutritional deficiencies and cachexia in Head and Neck Cancer patients18. MicroRNA-based nanomedicine for treatment of head and neck cancer19. MicroRNA-based clinical trials for head and neck cancer
