Description
This volume in the Diagnostic Pathology series is an ideal point-of-care resource for practitioners at all levels of experience and training. Covering the full range of solid organ transplantation (SOT) of the kidney, liver, heart, lung, pancreas, intestine, and more, it provides a current understanding of transplant immunology and pathology to help ensure accurate diagnosis for optimal clinical management. Richly illustrated and easy to use, Diagnostic Pathology: Transplant Pathology, third edition, is a visually stunning, one-stop reference for practicing pathologists, transplant practitioners, and students of organ transplantation.- Covers all areas of transplant pathology, incorporating the collective knowledge and experience from a team of transplant pathology experts with the latest updates from the 2022 Banff classification- Groups content by specific organ transplant, including kidney, liver, heart, lung, intestine, pancreas, and vascularized composite allotransplantation- Features sweeping updates throughout, including new chapters on transplant immunology that cover chronic viral infections and the immune response, immune manipulation and accommodation, and graft-vs.-host disease- Contains a new chapter on islet cell transplantation and new, detailed information on xenotransplantation—specifically kidney xenograft- Covers advances in vascularized composite allografts (hands, face, uterus, phallus) transplantation- Features more than 1,500 superb images, including histology, gross pathology, full-color illustrations, and radiologic images- Employs consistently templated chapters, bulleted content, key facts, annotated images, and an extensive index for quick, expert reference at the point of care- Any additional digital ancillary content may publish up to 6 weeks following the publication date
Table of Contents
SECTION 1: IMMUNOLOGY4 Immune Response in Organ TransplantationRoshini Sarah Abraham, PhD8 Regulatory Immune Cells and Transplant ToleranceRoshini Sarah Abraham, PhD14 Viral Infections and Immune ResponseSanya J. Thomas, MD and Roshini Sarah Abraham, PhD20 Genetics of Complement Variants in Atypical HUS and TMARoshini Sarah Abraham, PhD24 Laboratory-Based Immune Monitoring in Organ TransplantationSanya J. Thomas, MD and Roshini Sarah Abraham, PhD30 Introduction to XenotransplantationRoshini Sarah Abraham, PhD32 Graft-vs.-Host Disease in Solid Organ TransplantationSanya J. Thomas, MD and Roshini Sarah Abraham, PhDSECTION2: HLA TESTING36 Human Leukocyte Antigen SystemManish J. Gandhi, MD38 Histocompatibility TestingManish J. Gandhi, MD40 Transplantation and HLAManish J. Gandhi, MD44 ABO Blood Group Antigens and TransplantationManish J. Gandhi, MD46 Apheresis and TransplantationManish J. Gandhi, MD48 HLA and TransfusionManish J. Gandhi, MDSECTION 3: IMMUNOSUPPRESSIVE DRUGS52 Mechanism of Action of Immunosuppressive DrugsLoralie Langman, PhD and Florian Lemaitre, PharmD, PhD54 Therapeutic Drug Monitoring in Transplant PatientsLoralie Langman, PhD and Florian Lemaitre, PharmD, PhD58 History of Immunosuppression Drugs in TransplantationLoralie Langman, PhD and Florian Lemaitre, PharmD, PhDSECTION 4: KIDNEY TRANSPLANTATION62 History of Kidney TransplantationLynn D. Cornell, MD64 Pathologic Classification of Renal Allograft DiseasesRobert B. Colvin, MD66 Examination of End-Stage KidneyShane Meehan, MB, BCh72 Evaluation of End-Stage KidneyShane Meehan, MB, BCh78 Evaluation of Allograft KidneyLynn D. Cornell, MD and Evan Farkash, MD, PhD84 Evaluation of Donor KidneyLynn D. Cornell, MD and Evan Farkash, MD, PhD90 Evaluation of Transplant NephrectomyShane Meehan, MB, BCh and Evan Farkash, MD, PhD94 Evaluation of FibrosisA. Brad Farris, III, MD, MBA98 Protocol BiopsiesLynn D. Cornell, MD and Evan Farkash, MD, PhD102 AccommodationLynn D. Cornell, MD104 ToleranceRobert B. Colvin, MDSURGICAL COMPLICATIONS108 Acute Allograft IschemiaA. Brad Farris, III, MD, MBA112 Size Mismatch Allograft InjuryAnthony Chang, MD and Yael K. Heher, MD, MPH114 Urine LeakA. Brad Farris, III, MD, MBA115 LymphoceleA. Brad Farris, III, MD, MBA116 Multinucleated EndotheliopathyJonathan Zuckerman, MD, PhD120 Transplant Renal Artery StenosisA. Brad Farris, III, MD, MBA122 Transplant Renal Artery or Vein ThrombosisA. Brad Farris, III, MD, MBA124 Kidney XenograftsIvy A. Rosales, MDALLOGRAFT REJECTION128 Hyperacute RejectionLynn D. Cornell, MD and Michael Mengel, MD132 Acute T-Cell-Mediated RejectionLynn D. Cornell, MD and Michael Mengel, MD142 Chronic T-Cell-Mediated RejectionLynn D. Cornell, MD and Michael Mengel, MD146 Acute Antibody-Mediated RejectionLynn D. Cornell, MD and Michael Mengel, MD154 Chronic Antibody-Mediated RejectionLynn D. Cornell, MD and Michael Mengel, MD166 Transcript Analysis of Renal Transplant BiopsiesMichael Mengel, MD and R. Neal Smith, MD, PhDRECURRENT AND DE NOVO DISEASES170 Diseases That Recur in AllograftsAnthony Chang, MD, Lynn D. Cornell, MD, and R. Neal Smith, MD, PhD176 De Novo Focal Segmental GlomerulosclerosisAnthony Chang, MD and Astrid Weins, MD, PhD178 De Novo Membranous NephropathyAnthony Chang, MD182 Anti-GBM Disease in Alport SyndromeAnthony Chang, MD and R. Neal Smith, MD, PhD184 Chimerism Transition SyndromeA. Brad Farris, III, MD, MBA186 Late Posttransplant HistologyLynn D. Cornell, MDKIDNEY PATHOLOGY OF RECIPIENTS OF OTHER TRANSPLANTS188 Kidney Diseases in Nonrenal Transplant RecipientsRobert B. Colvin, MD192 Graft-vs.-Host GlomerulopathiesAnthony Chang, MD and Yael K. Heher, MD, MPHDRUG TOXICITIES194 Calcineurin Inhibitor ToxicityShane Meehan, MB, BCh200 mTOR Inhibitor ToxicityLynn D. Cornell, MDINFECTIONS202 Acute PyelonephritisNeeraja Kambham, MD210 Polyomavirus NephritisAnthony Chang, MD and Evan Farkash, MD, PhD218 Adenovirus InfectionAnthony Chang, MD and R.
