Description
Opioids have played a prominent role in society for centuries and have been lauded for both their analgesic and euphoric qualities by cultures throughout the world. The advent of medical and pharmaceutical sciences in the 20th century ushered in a wide variety of different commercial opioid products that were designed to maximize their therapeutic potential. As the use of opioids increased, a corresponding need emerged to understand more about how opioids exert their effects in the body and brain; the consequences of opioid use regarding physical dependence, withdrawal, and craving; how we might best treat opioid use disorder (OUD) and address risk for opioid-related overdose; and how opioids may intersect with other clinical conditions to produce unique challenges.Edited by Kelly E. Dunn, The Oxford Handbook of Opioids and Opioid Use Disorder synthesizes research across the spectrum, and establishes a foundational knowledge regarding historical and current epidemiological trends, neurobiological and genetic contributors to opioid effects and OUD, and core elements of opioid use such as withdrawal and craving. It provides specific information and guidance regarding opioid treatment paradigms, including chapters on specific pharmacotherapies as well as treatment approaches, and discusses considerations for special clinical populations. An overview of these respective issues is provided across 38 chapters, which outline the history and science of these topics alongside clinical considerations and case examples.Written by expert bench scientists, epidemiologists, clinical trial interventionists, medical practitioners, and harm reduction specialists, this handbook will serve as a comprehensive guide for practitioners, policymakers, students, and researchers who wish to achieve a better understanding of the complex world of opioid and OUD practice and science.
Table of Contents
Chapter 1: Historical Events that Shaped Contemporary Opioid Trends Kelly E. DunnChapter 2: Epidemiology of Opioid Use and Smoking, Alcohol, and Polysubstance Use Among Persons Using Opioids Maria A. Parker and Whitney S. Cordoba-GruesoChapter 3 Opioid Use Disorder: Diagnostic History and Current Understanding Orrin D. Ware and Kelly E. DunnChapter 4: Access to Treatment for Opioid Use Disorder Brendan Saloner and Jason GibbonsChapter 5: The Current Status of Medical Student Education on Opioids Oluwole Jegede, Peter J. Na, Ismene Petrakis, and Srinivas B. MuvvalaChapter 6: The Neurobiology of Opioid Use Shailesh N. Khatri, Erin E. Maher, Emma O. Bondy, and Cassandra D. GipsonChapter 7: Genetic Influences in Opioid Use Disorder Jill Rabinowitz and Brion MaherChapter 8: The Opioid Withdrawal Syndrome: Presentation, Measurement, and Management Kelly E. Dunn, Cecilia Bergeria, Orrin D. Ware, Eric C. StrainChapter 9: Neonatal Abstinence Syndrome Sarah H. Heil, Heidi S. Melbostad, and Leigh-Anne CioffrediChapter 10: Opioid Craving: Understanding Its Measurement, Mechanisms, and Treatment Cecilia Bergeria and Brandon ParkChapter 11: Opioids and Cognition Bethea A. Kleykamp, Shannon B. Clarke, and Shauna P. AcquavitaChapter 12: Opioid Effects on Sleep: Review of the Literature and Consideration of the Hypothalamic-Pituitary-Adrenal Axis as a Relevant Mechanism Jennifer D. Ellis, Chung Jung Mun, and Patrick H. FinanChapter 13: Fentanyl Kelly E. Dunn, H. Elizabeth Bird, and Caitlyn J. DurginChapter 14: Tramadol Kelly E. Dunn, Judy Ashworth, and Eric C. StrainChapter 15: Kratom (Mitragyna speciosa): Pharmacology and Use of a Naturally Occurring Atypical Opioid Kirsten E. Smith, Oliver Grundmann, Marc T. Swogger, and Albert Garcia-RomeuChapter 16: Ibogaine and Noribogaine Deborah C. Mash and Michael KarukinChapter 17: Abuse Deterrent and Sustained Release Opioid Formulations Rachel R. Luba, Sandra D. Comer, and Edward V. NunesChapter 18: Methadone Jonathan R. Buchholz, Molly Kalmoe, Justin Stamschror, and Andrew J. SaxonChapter 19: Buprenorphine Eric C. Strain and Andrew GaddisChapter 20: Naltrexone Marina Tsoy-Podosenin and Evgeny KrupitskyChapter 21: Clonidine Mark S. Gold and Kenneth BlumChapter 22: Lofexidine Charles W. Gorodetzky, Kristen L. Gullo, and Marc FishmanChapter 23: Injectable Opioid Treatment Eugenia Oviedo-JoekesChapter 24: Long-Term Treatment of Opioid Use Disorder With Medications Aaron S. Wolfgang, Melissa B. Weimer, Peter J. Na, David A. Fiellin, and Srinivas B. MuvvalaChapter 25: Supervised Withdrawal Opioid Use Disorder Treatments Kelly E. Dunn and Andrew S. HuhnChapter 26: Psychosocial Treatment Methods Jessica M. Peirce, Denis G. Antoine, Alexis S. Hammond, and Michael S. KidorfChapter 27: Behavioral and Self-directed Treatments for Opioid Use Disorder Wendy Insalaco and J. Gregory HobelmannChapter 28: Contingency Management Treatment of Opioid Use Disorder August F. Holtyn, Forrest Toegel, and Matthew D. NovakChapter 29: Treating Opioid Use During Pregnancy and Postpartum Life Phases Hendr?e E. JonesChapter 30: Pharmacy-Based Treatment Options for Opioid Use Disorder Ali Cheetham and Suzanne NielsenChapter 31: Opioid Overdose: Mechanisms and Naloxone Jermaine D. Jones, Rachel R. Luba, Mudassir Mumtaz, and Felipe CastilloChapter 32: Opioid Overdose: Intervention Strategies Laura BrandtChapter 33: Supervised Consumption Services Jeanette Bowles, Meaghan Thumath, Gillian Kolla, Zoe Dodd, Jaime Arredondo Sanchez Lira, Frank Crichlow, and Leo BeletskyChapter 34: Psychiatric Comorbidities Among Persons Who Are Using Opioids R. Kathryn McHughChapter 35: Sex as a Biological Variable and Gender as a Social Construct in the Treatment of Opioid Use Disorder Andrew S. HuhnChapter 36: Challenges of Opioid Use Disorder in Rural Settings Stacey C. Sigmon and Jennifer R. HavensChapter 37: Differences Between Those Engaged in Heroin Use and Non-Prescribed Opioid Use Ty S. Schepis, Bowie Duncan, and Katherine VrotsosChapter 38: The Impact of Opioid Use Disorder on Families and Children Erin L. Winstanley, Amanda Newhouse, and Kari-Beth Law
