Description
Toxicodynamics in Drug Research, Volume 2: Public Health and Toxicology Issues examines the implications of public health issues and the impact of pharmaceuticals, chemical and food toxicants, dietary phytochemicals, and medical treatments on human health.Volume 2: Public Health and Toxicology Issues in Drug Research: Toxicity and Toxicodynamics covers topics on pharmacokinetics and toxicokinetics such as population pharmacokinetics/toxicokinetics, the design of toxicokinetic studies, and the use of toxicokinetic data in preclinical safety assessments. The book investigates the health effect caused by the bioaccumulation of pharmaceutical and personal care products and the impact of drug-induced toxicity on different systems of the body. It discusses the mechanistic pathways of food toxicants and illustrates the molecular mechanisms of the chemopreventive role of dietary phytochemicals. It also delves into the toxic effects of medical treatments and materials. Ethical, legal, societal, and professional issues in toxicology round off the coverage providing a valuable resource to interested in learning more about the health impact and public health issues related to the toxicity of pharmaceuticals, dietary supplements, personal care products, and medical treatments.- Discusses the impact of pharmaceuticals, food, and chemical toxicants on human health- Examines the toxic effects of medical treatments, clinical administrations, and materials- Explores public health issues around drug safety and toxicology
Table of Contents
1. Biomarkers: Revolutionizing disease monitoring and therapeutic strategiesAnand More, Simranjit Kaur, Sakshi Bhatele, Nupur Vasdev, Tanisha Gupta, Bhakti Pawar and Rakesh Kumar Tekade2. Connecting biotransformation with toxicitySimranjit Kaur, Muktika Tekade, Bhakti Pawar, Nupur Vasdev, Tanisha Gupta, Nagaraja Sreeharsha and Rakesh Kumar Tekade3. Idiosyncratic drug reactions and toxicitiesTanisha Gupta, Yogesh Wankhede, Muktika Tekade, Amrita Singh, Nupur Vasdev, Bhakti Pawar, Manoj Kumar and Rakesh Kumar Tekade4. Importance of dose selection in toxicity studiesMamata Panchal, Simranjit Kaur, Bhakti Pawar, Tanisha Gupta, Nupur Vasdev, Muktika Tekade and Rakesh Kumar Tekade5. Implication of sex differences in toxicologyAnand More, Simranjit Kaur, Muktika Tekade, Vipulata Yeole, Prashant L. Pingale, Dattatraya Shinkar and Rakesh Kumar Tekade6. Toxicological risk assessment and risk managementSuresh Shinde, Simranjit Kaur, Muktika Tekade, Bhakti Pawar, Tanisha Gupta, Nupur Vasdev, Basel Arafat and Rakesh Kumar Tekade7. Adverse outcome pathway: A paradigm shift in chemical toxicological analysisSakshi Bhatele, Mahi Mhatre, Muktika Tekade, Nupur Vasdev, Bhakti Pawar and Rakesh Kumar Tekade8. Design of toxicokinetic studiesSimranjit Kaur, Muktika Tekade, Nupur Vasdev, Bhakti Pawar, Tanisha Gupta, Aprameya Ganesh Prasad and Rakesh Kumar Tekade9. Use of toxicokinetic data in preclinical safety assessmentSimranjit Kaur, Muktika Tekade, Nupur Vasdev, Bhakti Pawar, Shubham Mule, Girish Meravanige Basavarajappa and Rakesh Kumar Tekade10. Drug-induced cardiotoxicityVinayak Pawar, Yogesh Wankhede, Simranjit Kaur, Bhakti Pawar, Nupur Vasdev, Tanisha Gupta, Pinaki Sengupta and Rakesh Kumar Tekade11. Drug-induced immunotoxicityMahi Mhatre, Suresh Shinde, Simranjit Kaur, Nupur Vasdev, Muktika Tekade, Bhakti Pawar, Adil Ali Sayyed and Rakesh Kumar Tekade12. Drug-induced photosensitivityBhakti Pawar, Yogesh Wankhede, Gurpreet Banth, Muktika Tekade, Tanisha Gupta, Richa Dayaramani and Rakesh Kumar Tekade13. Toxic effects of cancer therapiesShweta Ingole, Nupur Vasdev, Muktika Tekade, Tanisha Gupta, Bhakti Pawar, Mahi Mhatre, Aprameya Ganesh Prasad and Rakesh Kumar Tekade14. High content screening in toxicologyMamata Panchal, Bhakti Pawar, Muktika Tekade, Nupur Vasdev, Tanisha Gupta, Piyush Gondaliya and Rakesh Kumar Tekade15. High-throughput screening in toxicity assessmentKuldeep Rajpoot, Mamata Panchal, Bhakti Pawar, Nupur Vasdev, Tanisha Gupta, Muktika Tekade, Manish Sharma and Rakesh Kumar Tekade16. Population pharmacokinetics/toxicokineticsKuldeep Rajpoot, Muktika Tekade, Bhakti Pawar, Pinaki Sengupta and Rakesh Kumar Tekade17. Quantitative extrapolation interspecies scaling/low-dose extrapolationShivam Otavi, Tanisha Gupta, Muktika Tekade, Amrita Singh, Pinaki Sengupta, Ashish Agrawal and Rakesh Kumar Tekade18. Toxicity and toxicodynamics of cryoprotectant used in pharmaceutical productsPrashant L. Pingale, Amarjitsing P. Rajput, Yash S. Chavan, Rupali A. Patil, Amrita Singh and Rakesh Kumar Tekade19. Insect repellents as an environmental chemical toxicant to human healthPratik Katare, Suryanarayana Polaka, Lakshmi Vineela Nalla, Vaishali Makwana and Rakesh Kumar Tekade20. Clinical toxicity of antibodyedrug conjugatesTanisha Gupta, Mamata Panchal, Vinayak Pawar, Muktika Tekade, Sanyam Gandhi and Rakesh Kumar Tekade21. Cumulative toxicity of herbal drugsAnand More, Shweta Ingole, Tanisha Gupta, Nupur Vasdev, Muktika Tekade, Randa SH. Mansour and Rakesh Kumar Tekade22. Radiotherapy toxicityMamata Panchal, Shubham Mule, Yogesh Wankhede, Muktika Tekade, Tanisha Gupta, Aprameya Ganesh Prasad and Rakesh Kumar Tekade23. Toxicities and toxicodynamic of anestheticsSimranjit Kaur, Md Abubakar, Bhaskar Jyoti Dutta, Bhakti Pawar, Muktika Tekade, Prashant L. Pingale and Rakesh Kumar Tekade24. Toxicity of nanomaterialsAnoothi Bain, Nupur Vasdev, Muktika Tekade, Dinesh Kumar Mishra, Pinaki Sengupta and Rakesh Kumar Tekade25.
