新薬開発におけるクオラムクエンチングの視点<br>Perspectives of Quorum Quenching in New Drug Development

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新薬開発におけるクオラムクエンチングの視点
Perspectives of Quorum Quenching in New Drug Development

  • 言語:ENG
  • ISBN:9781032286457
  • eISBN:9781040018743

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Description

Antibiotic resistance in pathogen microorganisms is a major global concern, especially the formation of biofilms. Quorum quenching has been practically used to control biofilm growth, and this indicates a promising hope for the development of new drugs for the control of biofilm-forming pathogens. This book provides a single source of information about two issues: the biology of quorum sensing and quorum quenching, and the perspectives of quorum quenching in new drug development. The text covers the latest literature from the last ten years and insights into quorum quenching and its need in medicine as an anti-virulence strategy.

Features:

  • Exclusively focuses on quorum quenching and its ability to be used as an alternative to antibiotics in the control of multidrug-resistant pathogens.

  • Reviews the latest literature and case studies of the last ten years in the field of quorum sensing and quorum quenching.

  • Promotes a new approach to the development of the next generation of antibacterial drugs.

  • In the wake of rising antibiotic drug resistance, it is crucial to develop an alternative approach to control bacterial infection diseases and quorum quenching appears to be a promising strategy in the development of new medicines.

Table of Contents

Chapter 1 Biofilms of Pathogenic Bacteria

Chapter 2 Biofilm regulation and Quorum sensing in Bacterial Pathogens

Chapter 3 Quorum sensing in Extremophiles

Chapter 4 Single and dual species biofilms of human pathogenic bacteria and Application of bacteriophages on biofilms

Chapter 5 Methods for extenuating biofilms associated drug resistance by micro and nano-tech effectiveness and progress of anti-bfs therapy stratagems and proceeded perspective by micro-crystals and nano-crystals

Chapter 6 Ecological Relevance of Quorum Quenching

Chapter 7 Quorum Quenching in Biofilm Mitigation

Chapter 8 The Hypothalamic-Pituitary-Testicular Axis in Drug Development for Androgens Across Sex, and Lifespan

Chapter 9 The GH-IGF1 Axis and the Hypothalamus–Pituitary–Testicular Axis in Drug Development

Chapter 10 Reproductive Endocrinology Drug Development Hormones, Metabolism, and Fertility in Female Reproductive Health

Chapter 11 Novel Drugs - Clinical trials and Approval process

Chapter 12 Quorum Quenching-based drug development-Challenges and Futurity

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