Description
Many plant-derived bioactive compounds are the foundation effective drugs to cure diseases. Usually, the bioactive compounds in plant biomass are low, and the extraction of bioactive compounds from plants is not eco-friendly, which limits their application in drugs and other industries. With the development of synthetic biology and green biomanufacturing, the biosynthesis of complex bioactive compounds is possible. However, the engineering fundamentals for microbial biosynthetic of plant-derived bioactive compounds is vast. Engineering biology for microbial biosynthesis of plant-derived bioactive compounds summarizes the engineering fundamental biotechnologies for microbial production of plant-derived bioactive compounds, allowing this content to be easily accessed. Coverage includes summaries of key achievements, identification of challenges, current approaches, tips and tricks, and helpful insights into critical bottlenecks.With a comprehensive coverage of the field, Engineering biology for microbial biosynthesis of plant-derived bioactive compounds is of great interest to undergraduate and graduate students, scientists, researchers as well as engineers who work on the microbial production of plant-derived bioactive compounds.- Provides valuable information for engineers, scientists, and industrial researchers who want to obtain microbial strains with the ability of plant-derived bioactive compound production- Guides microbial production of plant-derived bioactive compounds at the laboratory and industrial levels- Ideal resource for anyone who works on the microbial production of plant-derived bioactive compounds
Table of Contents
1. Mining bioparts for the biosynthesis of plant-derived bioactive compounds via omics and bioinformatics technologies Zheyong Xue, Yanlin Li, Xue Yin, Yanhong Guo and Jia Liu 2. DNA assembly techniques for the reconstitution of plant natural product biosynthetic pathways in Saccharomyces cerevisiae Jiazhang Lian 3. The application of gene-editing technologies in the biosynthesis of plant-derived bioactive compounds Xin Sun, Meng Li, Yiting Mei and Meirong Jia 4. Pathway engineering of plant-derived bioactive compounds in microbes Yun Liu, Dadeng Zhang, Tongjian Yang, Ruidong Chen and Xiaozhou Luo 5. Construction and application of a genome-scale metabolic network model for plants Jinyi Qian and Chao Ye 6. Metabolic design—build—test—learn cycle used for the biosynthesis of plant-derived bioactive compounds Yongkun Lv and Weigao Wang 7. Microbial cell factories for the synthesis of plant-derived bioactive compounds: metabolic flux dynamic regulation Yameng Xu, Xiaoyang Ge, Ximan Hu, Xinrui Chen, Zhitian Zhang and Yonglin Zhang 8. Yeast cell factories for the biosynthesis of plant-derived bioactive terpenoids Yapeng Zhang and Chun Li 9. Nonconventional yeast cell factories for the biosynthesis of plant-derived bioactive terpenoids Qi Guo and Tian-Qiong Shi 10. Nonconventional yeast cell factories for the biosynthesis of plant-derived bioactive flavonoids Lin Hu, Liuheng Huang, Huihui Qiu, Fenghui Zhang, W.H. Nishani De Soyza, Ning He and Mingfeng Cao 11. Non-yeast fungal cell factories for the biosynthesis of plant-derived bioactive compounds Gen Zou 12. Fine-tuning and dynamic control of microbial cell factories for the biosynthesis of plant-derived bioactive compounds Lidan Ye 13. Biofoundries for plant-derived bioactive compounds Lihang Xie 14. Engineering biology fundamental for plant-derived bioactive compounds: challenges and prospects Ruibing Chen and Lei Zhang 15. Reprogramming microbial cell factories to overproduce plant natural products through directed genome evolution Zhihui Shi and Guokun Wang
