加齢の科学と医学 Aging : How Aging Works, How We Reverse Aging, and Prospects for Curing Aging Diseases

著者名：Fossel MD, PhD, Michael (EDT)

Academic Press（2024/02/29発売）

• 言語：ENG
• ISBN：9780443155000
• eISBN：9780443155017

Description

Aging: How Aging Works, How We Reverse Aging, and Prospects for Curing Aging Diseases explains the process of aging beyond mere entropy, exposing it as a complicated and dynamic process that undercuts maintenance and permits age-related disease. With a deeper understanding of the aging process, intervention becomes both easy to understand and clinically feasible.With a solid academic approach, this proposed book builds upon the substantial work published over the past 20 years, citing the newest data, up-to-date models based upon that data, and the implications for improved clinical intervention, including recent developments in gene and cell therapy. Coverage of age-related diseases includes neurodegenerative, cardiovascular, bone and joint, immune system, renal, pulmonary, and skin aging. Future directions of the field focus on interventions, including a summary of previous attempts to intervene in aging and age-related disease, the status of current research, and proposed biotech interventions, as well as their potential obstacles, risks, and benefits. This is the perfect reference for scientists, clinicians, and researchers interested in the translational research opportunities such as drug discovery, pharmacogenetics, and experimental therapeutics, not only summarizing where the field stands, but giving a clear and cogent view of where clinical medicine is going in the next decade.- Provides a sophisticated, accurate, and clear explanation of aging- Gives a clear explanation of the fundamental role of cell aging in age-related disease- Offers a unified model for the role of epigenetic and telomere changes in cell aging- Outlines effective approaches to intervention in the fundamental aging process- Introduces upcoming interventions intended to both cure and prevent age-related diseases

Table of Contents

1. Introduction to Aging and Age-Related Disease2. Age-Related Disease: Central Nervous System3. Age-Related Disease: Cardiovascular System4. Age-Related Disease: Bones5. Age-Related Disease: Joints6. Age-Related Disease: Kidneys7. Age-Related Disease: Immune System8. Age-Related Disease: Skin9. Age-Related Disease: Lungs10. Age-Related Disease: Diabetes11. Age-Related Disease: Eyes12. Age-Related Disease: Cancer, Telomerase, and Cell Aging13. Age-Related Disease: Effective Intervention14. Summary