Description
Microbiota Brain Axis: A Neuroscience Primer provides neuroscience researchers with a comprehensive guide on how to conduct effective microbiota-brain research, understand the appropriate methodologies, and collect and analyze microbiota data. The book begins with an introduction to the importance of the microbiota-brain communication in development and how microbiota impact neurodevelopmental disorders, mental health and neurodegeneration. In addition, the book discusses advances in microbiota analysis tools and techniques for neuroscience related research.- Reviews the many approaches to manipulating the microbiota in animal studies - including the use of germ-free animals, antibiotics and diet - and covers the strengths and limitations of each- Outlines available microbiota research tools, such as 16S sequencing and shot-gun metagenomics- Provides a comprehensive guide to analyzing microbiota-related data and the many choices for bioinformatics
Table of Contents
1. The gut-brain axis2. What is a healthy microbiome?3. Gene-environment factors influence microbiota composition, diversity, and function4. Microbiota to brain communication5. Microbiota influence behaviour – work in animal models6. Microbiota influence brain systems – work in animal models7. Microbiota in neurodevelopmental disorders8. Microbiota in psychiatry9. Microbiota-brain interactions in aging and neurodegeneration10. Pharmacological treatments and the microbiome - Antibiotics and nonantibiotic drugs11. Microbial-related treatments12. Microbiota-related biomarkers for precision medicine and drug discovery
