選択的スプライシングと癌 Alternative Splicing and Cancer

著者名：Macha, Muzafar A. (EDT)/A. Bhat, Ajaz (EDT)/Batra, Surinder Kumar (EDT)

CRC Press（2024/05/03発売）

• 言語：ENG
• ISBN：9781032196596
• eISBN：9781040030684

Description

This book Alternative Splicing and Cancer explores the crucial role alternative splicing, a post-transcriptional process, plays in human health and diseases, particularly cancer. Diving deep into the complexities of gene expression and protein diversity, the book illuminates how abnormal splicing contributes to aggressive tumor formation, affecting cellular functions such as proliferation, survival, and immune evasion. With a focus on understanding molecular mechanisms, this book unravels potential diagnostic and prognostic targets, opening doors for enhanced anti-cancer treatment efficacy. An indispensable resource for anyone intrigued by the interplay between gene splicing and cancer biology, it paves the way towards innovative therapeutic strategies.

Table of Contents

Preface 1. Alternative Splicing and Human Diseases 2. Mechanism of RNA Splicing 3. Alternative Splicing: A New Cancer Hallmark 4. Deregulated Spliceosome and Splice Variants in Cancers 5. Deregulated Oncogenic Signaling Pathway(s) and Alternative Splicing 6. Alternative Splicing and Metastasis 7. Role of Splice Variant of Pyruvate Kinase M2 (PKM2) in Cancer Metabolism 8. Alternative Splicing and Immune Surveillance 9. Therapeutic Targeting of Alternative Splicing in Cancers 10. Alternative Splicing in Cancer Drug Resistance 10. A Systematic Evaluation of Alternative Splicing and Cancer: A Review Index.