トランスレーショナル糖鎖生物学と人体の健康・疾患 Translational Glycobiology in Human Health and Disease

著者名：Kilcoyne, Michelle (EDT)/Joshi, Lokesh (EDT)

Academic Press（2023/11/29発売）

• 言語：ENG
• ISBN：9780128196557
• eISBN：9780128220023

Description

Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture. However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. In recent years, advances in computational analytics (glycomics) have allowed us to better interpret and realize the importance of glycobiology in human health and disease, and glycans and their associated processes have been shown to play a significant role across a variety of disease types. As the biomedical sciences continue to adopt multi-omic and precision medicine approaches, a greater understanding of glycobiology is essential for maintaining healthy physiology and advancing disease treatment.Translational Glycobiology in Human Health and Disease offers a deep examination of glycobiology for experts and non-experts alike in areas ranging from the role of glycobiology in chronic and infectious diseases to advances in technologies for higher throughput analysis and diagnosis. While keeping human health in the forefront, this book integrates a thorough discussion of glycobiology fundamentals with its growing areas of application and societal impact. With emphasis throughout on the interdisciplinary nature of glycosciences, this book also features perspectives from the health, computational (glycoanalytics), materials, biopharmaceutical, and diagnostic sciences.Disease and speciality areas addressed include gycoimmunology, neuroglycobiology, commensal glycobiology, gut health, regenerative medicine and glycobiology, glycobiology and cancer, congenital disorders of glycosylation, infectious disease glycobiology, and parasite glycobiology. Computational approaches discussed, supporting the advance of new research, include advanced glycoanalytics, glycomics microarrays, glycoengineering, and glycol systems biology. Additionally, authors consider impact areas for society and public health, such as glycobiology and entrepreneurship, policy and regulatory requirements for glycosylation, future research, and translation to new diagnostics and drug discovery.- Provides a deep, foundational overview of glycoscience and its translational potential, highlighting glycobiology's growing role in human health and disease study- Examines a broad range of relevant disease areas and applications of glycobiology in policy and public health- Features chapter contributions from leading, international experts in the field, fully integrating perspectives from the health, computational, materials, biopharmaceutical, and diagnostic sciences

Table of Contents

Section 1: Glycobiology2. Carbohydrates and human glycosylation3. Carbohydrate-binding proteins4. Carbohydrate-active enzymesSection 2: Glycobiology and health5. Glycoimmunology6. Neuroglycobiology7. Commensal glycobiology and gut health8. Microbiota accessible carbohydrates and the gut microbiome9. Regenerative medicine and glycobiology10. Exosome glycosylation for signalling and functionSection 3: Glycobiology and disease11. Cancer12. Altered glycosylation in autoimmune diseases13. Metabolic diseases: Disorders of carbohydrate metabolism and lysosomal storage14. Congenital Disorders of Glycosylation15. Microbial infectious disease glycobiology16. Parasite glycobiology17. Glycobiology of neurodegenerative diseases18. Glycobiology of neural injury and regenerationSection 4: Glycotechnologies19. Diagnostics and novel carbohydrate recognition molecules20. Advanced glycoanalytics21. Glycomics microarrays22. Glycoengineering and systems biology23. Computational Glycobiology24. Carbohydrate-incorporated BiomaterialsSection 5: Glycobiology and Society25. Translational glycobiology and entrepreneurship for health26. Glycobiology: Public engagement and society27. Policy and regulatory requirements for glycosylation28. Public health and translational glycobiology29. Future perspectives/ summary