Description
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of nonneoplastic and neoplastic conditions of blood and bone marrow, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Blood and Bone Marrow is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, oncologist, hematologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.- Provides practicing pathologists with key details about new entities, newly recognized causes of morphologic change in blood and bone marrow abnormalities, and new strategies for appropriate workup of neoplastic processes—all with a focus on key tests and key differential diagnostic considerations- Helps pathologists recognize unique blood and bone marrow findings that can be an indicator for specific exposures, such as new medications, new targeted therapies, or toxins- Integrates updated technologies, newly recognized disorders, complications/features in blood and bone marrow, new targeted therapies, and the increased use of homeopathic remedies- Contains new chapters covering SARS-CoV-2 infection features in blood and bone marrow, myelodysplastic syndrome (MDS) mimics, blood and bone marrow findings linked to targeted therapies, blood and bone marrow findings linked to other medications, and more- Updates all existing chapters and contains expanded information on T-cell neoplasms in blood and bone marrow and intravascular large B-cell lymphoma in blood and bone marrow- Includes details from the World Health Organization (WHO) fifth edition Classification of Haematolymphoid Tumours and the very latest 2023 International Consensus Classification (ICC) publications, reflecting new and renamed diagnostic entities, tumor classification changes and updates, and terminology changes and updates- Discusses molecular testing strategies based on specific neoplasms and specific differential diagnostic consideration- Clearly delineates numerous genetic disorders often found in blood and bone marrow- Features more than 2,500 superb images, including histology and gross pathology photographs, full-color illustrations and graphics, clinical photographs and radiologic images, and many new tables and charts/algorithms- Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care- Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices
Table of Contents
SECTION 1: INTRODUCTION4 Hematopoiesis and Bone Marrow HistologyKathryn Foucar, MD14 Bone Marrow Examination and TechniquesKathryn Foucar, MD and Kaaren K. Reichard, MD26 Synoptic/Integrated Bone Marrow Reporting and Algorithmic TestingAmer Mahmoud, MD, FCAP and Cordelia Sever, MD, FCAP30 Overview of Constitutional and Acquired Bone Marrow DisordersKathryn Foucar, MDSECTION 2: ANEMIA38 Overview of AnemiaKathryn Foucar, MDACQUIRED ANEMIAS44 Anemias of Inflammation, Chronic Kidney Disease, and CancerQian-Yun Zhang, MD, PhD48 Iron Deficiency AnemiaQian-Yun Zhang, MD, PhD52 Autoimmune Hemolytic AnemiasQian-Yun Zhang, MD, PhD58 Alloimmune Hemolytic Anemia and Hemolytic Disease of NewbornQian-Yun Zhang, MD, PhD62 Microangiopathic Hemolytic AnemiaQian-Yun Zhang, MD, PhD, Jay S. Raval, MD, and Marian Rollins-Raval, MD, MPH68 Megaloblastic AnemiaKristin Hunt Karner, MD and Daniel Babu, MD76 Acquired Nonneoplastic Sideroblastic AnemiaBrittany Coffman, MD and Kaaren K. Reichard, MD80 Alcoholism-Associated AnemiaBrittany Coffman, MD, Kathryn Foucar, MD, and Kaaren K. Reichard, MD84 Anemia in Older AdultsKathryn Foucar, MD88 Copper Deficiency-Associated AnemiaCarla S. Wilson, MD, PhD92 Acquired Red Cell AplasiaKristin Hunt Karner, MD96 Transient Erythroblastopenia of ChildhoodKathryn Foucar, MD98 Parvovirus-Induced Red Cell AplasiaKristin Hunt Karner, MD102 Paroxysmal Nocturnal HemoglobinuriaKristin Hunt Karner, MD108 Acquired Aplastic AnemiaKathryn Foucar, MD and David R. Czuchlewski, MDCONSTITUTIONAL ANEMIAS112 ThalassemiaKristin Hunt Karner, MD118 Sickle Cell AnemiaKristin Hunt Karner, MD122 Glucose-6-Phosphate Dehydrogenase (G6PD) DeficiencyBrittany Coffman, MD and Kathryn Foucar, MD124 Pyruvate Kinase DeficiencyKristin Hunt Karner, MD126 Hereditary SpherocytosisCarla S. Wilson, MD, PhD132 Hereditary Elliptocytosis, Including Hereditary PyropoikilocytosisBrittany Coffman, MD, Kathryn Foucar, MD, and Kaaren K. Reichard, MD136 Diamond-Blackfan AnemiaDavid R. Czuchlewski, MD140 Fanconi AnemiaDavid R. Czuchlewski, MD144 Congenital Dyserythropoietic AnemiaKathryn Foucar, MD150 Congenital Sideroblastic AnemiaDavid R. Czuchlewski, MD154 Congenital Megaloblastic AnemiaDavid R. Czuchlewski, MDSECTION 3: ERYTHROCYTOSISCONSTITUTIONAL162 Congenital ErythrocytosisDavid R. Czuchlewski, MDACQUIRED166 Acquired ErythrocytosisKathryn Foucar, MDSECTION 4: BENIGN LEUKOCYTE DISORDERS IN BLOOD AND BONE MARROW172 Overview of Benign Leukocyte Disorders in Blood and Bone MarrowKathryn Foucar, MD176 PancytopeniaKathryn Foucar, MD184 NeutropeniaKathryn Foucar, MD190 NeutrophiliaKathryn Foucar, MD196 MonocytosisCarla S. Wilson, MD, PhD202 EosinophiliaCarla S. Wilson, MD, PhD210 BasophiliaKathryn Foucar, MD212 LymphocytosisQian-Yun Zhang, MD, PhD216 Lymphopenia, Constitutional and AcquiredQian-Yun Zhang, MD, PhD220 Plasmacytosis of Bone MarrowKathryn Foucar, MD228 Hematogones in Bone MarrowDevon Chabot-Richards, MD and Kaaren K. Reichard, MD238 Lymphoid Aggregates in Bone MarrowKathryn Foucar, MD and Kaaren K. Reichard, MD246 Granulomas in Bone MarrowKathryn Foucar, MDSECTION 5: CONSTITUTIONAL GRANULOCYTIC DISORDERS CONSTITUTIONAL NEUTROPENIAS254 Severe Congenital Neutropenia and Cyclic NeutropeniaDavid R. Czuchlewski, MD258 Shwachman-Diamond SyndromeDavid R. Czuchlewski, MD262 Chediak-Higashi SyndromeDavid R. Czuchlewski, MD266 Myelokathexis in WHIM SyndromeKathryn Foucar, MDCONSTITUTIONAL NEUTROPHIL ANOMALIES270 Pelger-Huët AnomalyKathryn Foucar, MD274 MYH9-Related DisordersDavid R. Czuchlewski, MD278 Selected Lysosomal Storage Diseases With Abnormal Leukocyte GranulationDavid R. Czuchlewski, MDSECTION 6: MEGAKARYOCYTIC DISORDERS286 Overview of Megakaryocytic DisordersKathryn Foucar, MD, Marian Rollins-Raval, MD, MPH, and Kaaren K.
