Description
Coronaviruses can cause illness, severe disease, and death; for example, Middle East respiratory syndrome (MERS), severe acute respiratory syndrome (SARS), and COVID-19. Vaccine development and antiviral drugs are challenged by the propensity for viral mutations allowing these viruses to evade such therapies. There are a number of bioactive compounds from natural sources, which can exert health benefits and act as antiviral therapies such as anti-inflammation, antioxidative stress, and immune regulation. This book summarizes research on the potential efficacy and underlying mechanisms of bioactive compounds and traditional medicines against SARS-CoV-2.
Key Features
- Summarizes the potential benefits of bioactive therapies for coronaviruses
- Focuses on COVID-19, but also covers MERS and SARS
- Provides alternatives to vaccines and other antiviral drugs whose efficacy is reduced by viral mutations
- Relevant for clinicians and public health officials
Table of Contents
Chapter 1 - Omics-guided intervention strategies in combatting SARS-CoV-2: Recent advancements and challenges
Contributors: Somrita Padma, Nabarun Chandra Das, Ritwik Patra, Pritha Chakraborty, Abhijit Dey, Suprabhat Mukherjee
Chapter 2 - The application of computer-aided drug design methods for developing natural compounds-based therapeutics against SARS-CoV-2
Contributors: Priya Godara, Dhaneswar Prusty
Chapter 3 - Therapeutic targets of host factors for potential COVID-19 treatments
Contributors: Sabarinath Neerukonda
Chapter 4 - Phytocompounds: A paradigm shift as therapeutics for COVID-19
Contributors: Vijeta Prakash, Paridhi Bhatia, Shweta Dang, Pammi Gauba, Reema Gabrani
Chapter 5 - Flavonoids as potential therapeutic agents against the SARS-CoV-2 infection: An overview
Contributors: Anand Kumar Pandey, Shalja Verma
Chapter 6 - Antiviral activities of flavonoids against COVID-19 and other virus-causing ailments
Contributors: Arthi Boro, Biju Reji Souparnika, Srinivasan Atchaya, Shanmugam Ramya, Natchiappan Senthilkumar, Shanmugam Velayuthaprabhu, Rengasamy Lakshminarayanan Rengarajan, Arumugam Vijaya Anand
Chapter 7 - Potential therapeutic effects of flavonoids against the COVID-19 infection: The mode of action
Contributors: Aswani R.B, Honey Pavithran , Ranjith Kumavath
Chapter 8 - Terpene and Terpenoid: Potent antiviral agents against SARS-CoV-2
Contributors: Dwaipayan Sinha, Moumita Chatterjee, Srijonee Choudhury, Sanchita Seal, Tapas Das, Shilpi Sharma, Swastika Banerjee, Shahana Chowdhury
Chapter 9 - Phytonutrients and secondary metabolites to cease SARS-CoV-2 loop
Contributors: Ajith Sivasangar Latha, Poornima Prasad Anita, Nihala Sidhic, Elizabeth James, Mohandass Kaviya, Kathirvel Bharathi, Balasubramanian Balamuralikrishna, Arumugam Vijaya Anand
Chapter 10 - Treatment strategies against COVID-19 using bioactive compounds and plant secondary metabolites
Contributors: Syeda Aroosa Mohsin, Humaira Fatima, Rabia Javed
Chapter 11 - The potential contribution of vitamin K as a nutraceutical to scale down the mortality rate of COVID-19
Contributors: Shanmugam Ramya, Arthi Boro, Irudhayaraj Peatrise Geofferina , Arumugam Jananisri , Ganesh Vishalini , Balasubramanian Balamuralikrishnan, Meyyazhagan Arun, Arumugam Vijaya Anand
Chapter 12 - Gastrointestinal Symptoms in COVID-19 patients: Prevention and Treatment
Contributors: Mohamed Bouhrim, Noureddine bencheikh , Nour Elhouda Daoudi , Amine Elbouzidi , Hayat Ouassou , Loubna Kharchoufa , Doha Berraaouan , Jen-Tsung Chen , Christophe Hano, Mohamed Addi , Mostafa Elachouri, Mohamed Bnouham
Chapter 13 - Mechanisms and management options of liver injury in COVID19: A Review
Contributors: Daoudi Nour Elhouda, Bouhrim Mohamed, Bouziane Omar, Mamri Samira, Marghich Mohamed, Ouassou Hayat, Mohamed addi, Christophe Hano, Jen-Tsung Chen, Bnouham Mohamed
Chapter 14 - Marine species-derived bioactives against coronavirus disease
Contributors: Augustus Akshaya Rani, Samsudeen Malik Basha, Syed Saadullah Ashfaq, Roy Apoorva, Jana Sudipta, Shunmugiah Karutha Pandian
Chapter 15 - Potential bioactive compounds of Indian flora against SARS-CoV-2
Contributors: Deepyaman Das, Joydeep Chakraborty, Harshita Shand, Rittick Mondal, Soumita Podder, Suvankar Ghorai, Amit Kumar Mandal
Chapter 16 - Natural product-derived active compounds for the management of COVID-19: A summary from Indochina
Contributors: Sora Yasri; Viroj Wiwanitkit
Chapter 17 - Novel therapeutic strategy based on nanomedicine targeting thrombosis for SARSCoV-2
Contributors: Xingping Quan, Xiaofeng Gong, and Yonghua Zhao
Chapter 18 - Nanomaterials in combating human coronavirus infections
Contributors: Mohanapriya Chelladurai, Renganathan Sahadevan, Sekar Vijayakumar
Chapter 19 - Structural insights into drug targets from MERS, SARS-CoV, and SARS-CoV-2 and scope for phytochemicals as broad-spectrum anti-virals and immunomodulators.
Contributors: Nikhil Singh, Rafiq Mohamed, UV Babu, Raghavendra P Rao, Prachi Singh
Chapter 20 - Precision phytochemicals for COVID-19-induced olfactory dysfunction
Contributors: Sachiko Koyama, Vonnie D.C. Shields, Thomas Heinbockel
