Description
Mechanisms of Morphogenesis, Third Edition offers a bottom-up discussion of mechanisms of cell and tissue morphogenesis in a diverse array of organisms, including prokaryotes, animals, plants and fungi. Across foundational, applied and methods-based chapters, this book examines molecular nano-machines cooperation, generate cell shape, direct cell migration, and shape, form and rates of growth of various tissues in the body. Each topic is illustrated with experimental data from real systems, with particular reference to gaps in current knowledge and likely future developments, along with strategies to apply basic morphogenesis science across ever evolving applications.Newly added chapters feature case-study-driven discussions of morphogenesis in natural embryos and organoids, and illustrate how pathological morphogenesis can generate variants of body form. This edition has also been updated with analysis of large-scale and scale-invariant mechanisms, for example, morphogenesis by differential growth in mechanically connected tissues.- Includes over 200 full color figures and charts- Offers an integrated view of theoretical developmental biology and computer modeling with laboratory-based discoveries- Includes applied, case-study-driven discussion of experimental techniques- Is organized around principles and mechanisms, using them to integrate discoveries from a range of organisms and systems across new applications- Covers recent developments in morphogenesis research, including morphogenesis in organoids, other engineered tissues, and an analysis of large-scale and scale-invariant mechanisms
Table of Contents
Section I: Introduction1. General introduction – the aims and structure of this book.2. Key principles of morphogenesis3. The power and limitations of self-assemblySection II: Cell shape and the cell morphogenesis4. Morphogenesis of individual cells5. Animal cell shape: the importance of the cytoskeleton6. Cellular morphogenesis in plantsSection III: Cell Migration7. Cell migration in development: a brief overview8. The nanomachinery of locomotion9. Guidance by chemotaxis10. Guidance by galvanotaxis11. Guidance by contact12. Waypoint navigation in the embryo13. Cooperative migration of mesenchymal cells14. Condensation of cellsSection IV: Epithelial Morphogenesis15. The epithelial state: a brief overview16. Neighbour exchange and convergent extension17. Closure of holes18. Invagination and evagination19. Epithelial fusion20. Epithelial branching21. Boundaries to epithelial movementSection V: Morphogenesis by cell proliferation and death 22. Growth, proliferation and death: a brief overview23. Morphogenesis by orientated cell division24. Morphogenesis by elective cell deathSection VI: Morphogenesis in context25. From mechanisms to morphology: a brief overview26. Morphogenesis in embryos: some illustrative examples27. Morphogenesis in organoids, embryoids and engineered tissues28. Pathological morphogenesisSection VII: Modelling morphogenesis 29. Modelling morphogenesis: a brief overview30. Mechanical and mathematical models of morphogenesis31. Modelling using living cells – tissue engineering and synthetic morphologySection VIII: Conclusion and perspectives32. Conclusion and perspectives
