Description
This third edition of Medicinal Chemistry of Anticancer Drugs, provides an updated resource for students and researchers from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents.Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. This new edition includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theranostic anticancer agents, and pre-mRNA processing in cancer. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a unique and valuable perspective from the point of view of medicinal chemistry and drug design. It will be useful to undergraduate and postgraduate students of medicinal chemistry, pharmacology, biological chemistry, pharmacy and other health sciences. Researchers and practitioners will find a comprehensive treatment of the topic and a large number of references to reviews and the primary literature.- Provides a resource that is organized consistently based on targets and mechanisms of action from a molecular point-of-view- Focuses on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, providing a rationalization on the action of these type of drugs and the design of new active structures- Features a large number of color figures which give information in a clear-and-concise way- Includes extensive references to review articles and primary literature- Includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theragnostic anticancer agents, and pre-mRNA processing in cancer
Table of Contents
1. Introduction2. Antimetabolites3. Anticancer Drugs That Modulate Hormone Action4. Anticancer strategies involving radical species5. DNA Alkylating Agents6. Anticancer Drugs That Interact with the DNA Minor Groove7. Anticancer Drugs acting by DNA intercalation and topoisomerase inhibition8. Epigenetic Therapy of Cancer9. Anticancer Drugs Targeting Tubulin and Microtubules10. Drugs Tacting on signaling pathways, part 1: Tirosine kinase inhibitors11. Anticancer drugs acting on signaling pathways, part 212. Protein degradation-based cancer therapy13. Cancer immunotherapy14. Miscellaneous small-molecule and biological approaches to cancer therapy15. Drug Targeting in Anticancer Chemotherapy16. Drugs That Modulate Resistance to Anticancer Agents17. Cancer Chemoprevention
