Description
**Selected for Doody's Core Titles® 2024 in Clinical Genetics**Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic.This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications.- Features chapter contributions from leading international scientists and clinicians- Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization, placental development, embryo implantation, in vitro culture of the human embryo for the study of post-implantation development, and more- Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and –omics-based approaches- Includes all new chapters on evolving technologies and recent genetic discoveries of relevance to reproductive medicine
Table of Contents
Section I: Reproductive tract development and gametogenesis1. Developmental genetics of the male reproductive systemMarisol O'Neill, Victor A. Ruthig, Meade Haller, Boryana Zhelyazkova, Jeffrey T. White, Nannan Thirumavalavan, and Dolores J. Lamb2. Developmental genetics of the female reproductive tractJessica Garcia de Paredes, Michael Strug, Jordan Gosnell, Marcos Cordoba, and Jose M. Teixeira3. Genetics and genomics of early gonad developmentFanghong Ou, Zhangting Wang, Jinyue Liao, Hoi-Ching Suen, Kai Kei Miu, and Wai-Yee Chan4. Effects of aging on sperm chromatinHeather E. Fice and Bernard Robaire5. In vitro spermatogenesis from pluripotent stem cellsJin Du, Qing-Qin Gao, Cheng Huang, Hai-Ping Jiang, Mo-Yu Dai, Yu-Fei Li, Jun Wu, and Qi Zhou6. The molecular genetics of oogenesisFan Zhai, Xinyi Ma, Liying Yan, and Jie Qiao7. Growth of the mammalian oocyte: Focus on intercellular contact and communicationHugh J. Clarke8. In vitro activation of ovarian folliclesKazuhiro KawamuraSection II: Embryo implantation, placenta development and pregnancy9. Interaction of sperm and embryo with the female reproductive tractYin Lau Lee, Andy Chun Hang Chen, and William Shu Biu Yeung10. MicroRNAs in gametes and preimplantation embryos: Clinical implicationsAllison Tscherner, Nicholas Werry, Leanne Stalker, and Jonathan LaMarre11. Epigenetic modifications in the human placentaWendy P. Robinson, Maria S. Pen˜ aherrera, Chaini Konwar, Victor Yuan, and Samantha L. Wilson12. In vitro models of human blastocysts and early embryogenesisJia Ping Tan, Xiaodong Liu, and Jose M. Polo13. microRNAs in pregnancy: Implications for basic research and clinical managementPeng Xu, Xuan Shao, Ming Liu, and Yan-Ling Wang14. Human X-chromosome inactivation: Complexity and clinical implicationsMaria Jose Navarro-Cobos, Karanveer Bhangu, and Carolyn J. Brown15. The intergenerational effects on fetal programmingHe-Feng Huang, Guo-Lian Ding, Xin-Yuan Li, Xin-Mei Liu, and Zi-Ru JiangSection III: Infertility and assisted reproductive technology16. Theoretical and experimental strategies for preservation and restoration of male fertilityAli Honaramooz17. Update on the genetics and genomics of premature ovarian insufficiencyElena J. Tucker, Sylvie Jaillard, and Andrew H. Sinclair18. Premature ovarian insufficiencyYingying Qin, Ting Guo, Shidou Zhao, and Zi-Jiang Chen19. Genetics of polycystic ovary syndromeTristan Hardy, Alice P. Rogers, and Robert J. Norman20. Developmental origins and genetic basis of polycystic ovary syndromeT.M. Barber and S. Franks21. Genetic basis of metabolism and inflammation in PCOSYanli Pang, Yue Zhao, and Jie Qiao22. Genetics and genomics of recurrent pregnancy lossLaura Kasak, Kristiina Rull, and Maris Laan23. Genetics and genomics of endometriosisLinda C. Giudice, Richard O. Burney, Christian M. Becker, Stacey A. Missmer, Grant Montgomery, Nilufer Rahmioglu, Peter A.W. Rogers, and Krina Zondervan24. Human genetics and assisted reproduction in endometriosisYa-Ching Chou, Chien-Wen Chen, Endah Rahmawati, Guan-Lin Lai, Yun-Yi Ma, Yi-Xuan Lee, Ming-Jer Chen, and Chii-Ruey Tzeng25. Uterus transplantation as an infertility treatmentMats Brannstrom, Ali Khatibi, Ghada Hussein, and Pernilla Dahm-K€ahler26. Impacts of COVID-19 on reproductive health and prenatal geneticsPeng Yuan, Zhiqiang Yan, Wei Wang, Yao Li, Qilong He, Fan Zhai, Liying Yan, and Jie QiaoSection IV: Preimplantation/prenatal genetic diagnosis and screening27. Genomics in reproductive medicine: Current and future applicationsMaurizio Poli and Antonio Capalbo28. Molecular cytogenomics of human genetic disordersZirui Dong, Kwong Wai Choy, and Cynthia C. Morton29. Next-generation sequencing for gene panels, clinical exome, and whole-genome analysisMatthew A. Shanahan, Liesbeth Vossaert, and Ignatia B. Van den Veyver30.
