Description
Offering focused, practical, and up-to-date content on immunotherapies used to treat a wide variety of cancer types, Clinical Immuno-Oncology covers the basic cellular and molecular mechanisms involved in cancer initiation and progression. The text reviews the development of tumor specific antigens and the challenges of developing cancer immunotherapies. Every effort is made to relate the fundamental aspects of host immunity to the efficacy of current immunotherapies and how they work in conjunction with the immune system to combat cancer. This foundational resource explains the basics of cancer immunotherapy, discusses best practices, and provides recommendations from experienced clinicians in the field. Dr. John E. Niederhuber and a team of expert contributing authors provide clinically focused information essential for integrating these new therapies into practice—making this an ideal resource for fellows, practitioners, and other cancer team members in medical oncology, radiation oncology, cancer surgery, immunology, and cancer research.- Offers balanced and synthesized content on clinical science, clinical and translational research, and evidence-based practice for cutting-edge immunotherapies.- Discusses clinical applications of immunotherapies in common types of cancer including melanoma, breast cancer, pancreatic cancer, colon and rectum cancer, prostate cancer, leukemias, and hematologic malignancies.- Includes dedicated chapters on immune responses, innate immunity, active immunization against cancer, and cell-based therapies by leading experts.- Covers key topics such as cancer immunotherapy in the presence of COVID-19, immunotherapeutics, new findings concerning the role of the microbiome in immunotherapy, advances in engineered cell-based therapies, and active immunization against cancer.
Table of Contents
Tentative TOC:Introduction:Chapter 1.0 Development and Structure of the Lymphoid System- embryologic development- gross anatomy of the human immune system- lymphatic endothelial cells, heterogeneity of, and lymph node microscopic structure- lymph node function; afferent lymph cellular components- role of the gut microbiome in immune system development- specific functions related to the spread of cancer- cancer-induced lymphangiogeneis; sentinel LNs Chapter 2.0 The Chemistry, Structure, and Function of Immunoglobulins- immunoglobulin isotypes- the structure of immunoglobulins- the genetics of immunoglobulin diversity- antibody-dependent cellular cytotoxicity- heavy-chain C domain and role of glycosylation- the development of humanized monoclonals Chapter 3.0 The Role of the Complement System in Cancer- complement system activation pathways (classical, alternative and lectin)- the role of complement activation in cancer progression- complement regulatory proteins (CRPs) and cancer- the role of compliment activation in the tumor microenvironment enhances tumor growth- complement-dependent cytotoxicity in immune therapy of cancer- formation of the membrane attack complex (MAC)- potential application of anti-complement cancer therapies (C3aR/C5aR/IL-10 pathway) Chapter 4.0 Cancer as Non-Self4.1 primary generator of tumor-specific transplantation type antigens4.2 character of non-self, tumor associated antigens4.3 immune surveillance – innate immunity4.4 distinguishing between self and non-self4.5 toll-like receptors (TLRs); soluble bioactive proteins such as cytokines and C' proteins4.6 NK cellsChapter 5.0 The Adaptive Immune Response in Cancer- the diversity of active tumor antigen receptors- target specificity without limits in cancer-receptor variability- tumor antigen presentation; dendritic cells- immune response stimulation against the cancer- Cytotoxic T-cells and T-regulatory cells- B-cells and antibodies Chapter 6.0 The Science of Innate Immunity6.1 critical regulator of human inflammatory disease6.2 anatomic and physiologic barriers to pathogens – cancer causing viruses6.3 centrally a limited number of critical receptors6.4 the character of the inflammatory response6.5 lack of ability to form memory6.5 role in activating subsequent adaptive immune responseChapter 7.0 Immune Surveillance7.1 history of concept (Ilya Mechnikov 1908 Nobel Prize)7.2 evidence for immune surveillance today7.3 cancer in the immunocompromised hostChapter 8.0 Cancer – Avoiding Immune Detection8.1 cancer and the presence of immune resistance8.2 concept for the development of tumor cell toleranceChapter 9.0 Active Immunization Against Cancer and Cell-based Therapies9.1 infusing in-vitro expanded Tumor Infiltrating Lymphocytes (TILs)9.2 infusing dendritic cells pre-loaded with tumor specific oligopeptide antigens9.3 B7 co-activating receptor9.4 vaccinesChapter 10.0 The Three Major Clinical Components of Cancer Immunotherapy(modulating cell-mediated immune mechanisms)10.1 the role of and application of check point blockade10.2 the role and application of cell-based therapies including CAR-T cell therapies10.3 antibodies (and vaccines); monoclonal antibodies and novel application of bi- or tri-specificsChapter 11.0 The Clinical Application of Immunotherapeutics11.1 in melanoma cancer11.2 in breast cancer11.3 in pancreatic cancer11.4 in colon and rectum cancer11.5 in prostate cancer11.6 in leukemias and hematologic malignancies11.7 in other malignanciesChapter 12.0 Cancer Immunotherapy in the Presence of COVID-1912.1 immune response to coronavirus-2 infection12.2 CD8+ T cell depression during chronic viral infection and cancer12.3 checkpoint inhibitors in cancer patients with coronavirus infection12.4 coronavirus depletion of CD4+ T cells
