Description
This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&D has become one of the critical departments for pharmaceutical companies.
Features:
This book provides a new direction for scientists, researchers, and students in materials science and polymer chemistry who seek to better understand the chemistry behind conducting polymers and improve their performance for use in advanced energy applications.
Table of Contents
1. Reaction solvent selection
2. Reagent selection
3. Various reagent surrogates
4. Modes of reagent addition -control of impurity formation
5. Process optimization with additives
6. Process optimization of catalytic reactions
7. Process optimization of problematic reactions
8. Hazards of oxidation and reduction reactions
9. Other hazardous reactions
10. Hazardous reagents
11. Grignard reagent and related reactions
12. Challenging reaction intermediates
13. Protecting groups
14. Telescope approach
15. Design of new synthetic route
16. Stereochemistry
17. Various quenching strategies
18. Various isolation and purification strategies
19. Methods for residual metal removal
20. Methods for impurity removal
21. Pharmaceutical salts
22. Solid form
