Description
NK Cells in Cancer Immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies, focusing on NK cells to allow the best and precise combination treatments to cancer patients. The book provides existing background knowledge in the field of immunotherapy and discusses future areas of research required to carry out cutting-edge, validated therapies. Chapters cover advances in immunotherapeutic strategies, in particular, the use of NK cells with and without T-cell therapy in the treatment of cancer. The book is a valuable resource for cancer researchers, oncologists, graduate students and those interested in learning more about novel strategies to treat cancer patients.Immunotherapy is fast becoming the method of choice for cancer therapy. Although remarkable advances have been made in the field of immunotherapy, there are significant challenges and difficulties ahead since many of the current immunotherapeutic strategies do not provide long-lasting treatment strategies, and therefore are not very effective.- Covers CAR/T and CAR/NK and adoptive NK cell therapy with and without T cell therapies- Discusses basic biology of NK cells and mouse models of human cancers and the role of NK cells in metastatic cancer and in cancer stem cells- Encompasses information on combination therapies using check point inhibition, adoptive transfer of cytotoxic effector cells, chemotherapeutic drugs and activating and inhibitory antibodies
Table of Contents
1. Introduction and basic biology of NK cells2. Immunotherapy using CAR/NK with and without CAR/T3. Immunotherapy using NK cells with and without T cells and Tumor infiltrating lymphocytes as well as NK/T cells4. Autologous vs allogeneic sources of NK and T cell effectors5. Reversing NK inhibitory tumor microenvironment by targeting suppressive immune effectors6. Check point inhibitors7. Combination of NK immunotherapy with chemotherapy and radiation8. NK cell immunotherapy using ADCC inducing antibodies9. Oncolytic viruses and NK cell immunotherapy10. NK cell diagnostics11. Novel cell delivery systems
