Description
Autophagy Dysfunction in Alzheimer's Disease and Dementia provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzheimer's. The book discusses the implication of autophagy dysfunction in these diseases and how it causes degenerated proteins, including aggregated tau and aggregated amyloid protein. Other sections explores the possibilities of potential drug development through autophagy modulation, making this a great resource on the study of how autophagy dysfunction has been linked to the accumulation of misfolded proteins that cause death of neurons in Alzheimer's and other neurodegenerative diseases.- Discusses the implication of autophagy dysfunction in neurodegenerative diseases- Highlights the mechanisms involved in protein degradation- Explores the possibilities of drug development through autophagy modulation
Table of Contents
Section I. Degradation mechanisms of cells1. Degradation mechanisms of cellsSection II. Lysosomes2. Lysosomes-neuronal degeneration in lysosomal storage disordersSection III. The autophagic pathways3. The autophagy pathway and its key regulatorsSection IV. Amyloid beta protein and autophagy 4. Basics of amyloid beta protein in Alzheimer's disease5. Molecular linkages among Aβ, tau, impaired mitophagy, and mitochondrial dysfunction in Alzheimer's disease6. Endocytosis in β-amyloid biology and Alzheimer's diseaseSection V. Autophagy and tau protein 7. Autophagy and tau protein 8. BAG3 promotes tau clearance by regulating autophagy and other vacuolar-dependent degradative processes 9. Tau propagation and autophagySection VI. Autophagy and pathology in Alzheimer's disease 10. Granulovacuolar degeneration in neurodegeneration11. Autophagy dysfunction in skeletal myopathies: Inclusion body myositis and Danon diseaseSection VII. Autophagy and other disorders causing dementia12. Autophagy in Lewy body diseases and multiple system atrophy 13. Autophagy and Huntington's diseaseSection VIII. Drug discovery in Alzheimer's disease by modulating autophagy14. Drug discovery in Alzheimer's disease by regulating autophagy15. Drug discovery in Alzheimer's disease using metal chelators: Warning toward their uses16. Development of autophagy enhancers for Parkinson's disease therapy
