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Description
Drug Development for Malaria
Provides readers with first-hand advice for the development of novel antimalarial drugs
This book provides a systematic overview of antimalarial drug development and presents a wealth of data and insight from drug developers across three continents, including many from countries where the disease is endemic. Throughout, the contributions have been written with the drug developer in mind, highlighting challenges but also opportunities for the successful development of effective antimalarial drugs. Case studies and method-oriented chapters provide an abundance of practical first-hand advice on how to successfully develop an antimalarial drug.
Key topics covered in the book include:
- The performance of current drugs and therapies, the influence of formulation and targeted delivery, and strategies to overcome drug resistance.
- Technologies and approaches for development of novel drugs, such as assays, computer-aided drug design, known and potential drug targets, and natural sources for novel antimalarial compounds
- Vaccination as an alternative to drug therapy
For chemists and other professionals working in industries related to medicine and pharmaceuticals, this book provides a completely comprehensive overview of the current state of novel antimalarial drugs and how they can be developed in an efficient and cost-effective manner.
Table of Contents
INTRODUCTION
Past, Present and Future Drug Development for Malaria CHALLENGES AND OPPORTUNITIES IN MALARIA THERAPY
Scientific Challenges and Treatment Opportunities in the Face of Shifting Malaria Epidemiology
Recent Advances in Malaria Vaccine Development
Emerging Formulation Technologies against Malaria Resurgence
Targeted Drug Delivery for Malarial Therapy
The Imminent Threat of Antimalarial Drug Resistance
Current Therapies and New Drug Targets for the Future Drug Development of Drug Resistant Malaria
Bringing an Antimalarial Drug to Market
DRUG DEVELOPMENT
Assays for Antimalarial Drug Discovery
Role of Computer Aided Drug Design (CADD) in Designing Anti-malarial Agents
Aminoacyl-tRNA Synthetases as Malarial Drug Targets: A Structural Biology Perspective
Role of Natural Compounds for Prevention and Treatment of Malaria
Natural Products as a source for Antimalarial Drug Development Process
An Overview into the Anti-plasmodial South African Medicinal Plants
The Antimalarial Potential of Mushrooms
CASE STUDIES
Discovery and Trends of 8-Aminoquinoline and 4-Aminoquinoline Classes of Antimalarials
Discovery and Development of Artemisinin
Synthesis, Characterization and Antimicrobial Drug Efficacy of the Oxaborole Derivatives
Discovery and Development of beta (β)-Carboline Derivatives as Anti-malarial Agents
