Autophagy and Metabolism : Potential Target for Cancer Therapy

著者名：Kumar, Dhruv (EDT)/Asthana, Shailendra (EDT)

Academic Press（2022/08/06発売）

• 言語：ENG
• ISBN：9780323998796
• eISBN：9780323999458

Description

Autophagy and Metabolism: Potential Target for Cancer Therapy presents updates on autophagy in cancer metabolism and how it can be used to develop new, more efficient treatments. Written by experts in the field, the book presents recent research and explains how to translate it to the clinical setting. Sections discuss tumor cell metabolism and autophagy as therapeutic targets, autophagy regulation in cancer, signaling pathways in metabolic dysregulation in solid tumors, metabolic stress and cell death pathways, and the role of the tumor microenvironment. In addition, topics cover combined targeting autophagy, metabolism for cancer therapy, and the autophagy effect on immune cell metabolism.This will be a valuable resource for researchers, oncologists, graduate students, and members of the biomedical field who are interested in learning more about the interaction between autophagy and cancer metabolism.- Presents valuable and updated information on the mechanisms of autophagy in cancer metabolism- Discusses the various metabolic pathways linked with autophagy that can be a major target for chemotherapeutic strategies- Explains how autophagy supports tumor growth by activating metabolic phenotypes in cancer cells and the therapeutic interventions available to halt the process

Table of Contents

1. Role of metabolic dysregulation in cancer progression2. Role of Autophagy in Cancer Metabolism: Molecular Mechanisms3. Tumor Cell Metabolism and Autophagy as Therapeutic Targets4. Autophagy Regulation in Cancer: Current Knowledge on Action and Therapy5. Signaling pathways in metabolic dysregulation in solid tumors6. Metabolic Stress in Autophagy and Cell Death Pathways in Cancer7. Role of Tumor Microenvironment in Autophagy and Metabolism in Cancer8. Autophagy and Metabolic Regulation in cancer stem cells: molecular mechanisms and therapeutic applications9. Mitophagy in cancer and cancer stem cells: a role in metabolic reprogramming10. Combined targeting autophagy and metabolism for cancer therapy11. Designing metabolic target specific inhibitors for cancer therapy12. Effect of autophagy on immune cell metabolism and the effect of metabolites on autophagy activity