Description
Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals.- Covers different aspects of anti-aging research, from foundational knowledge to future perspectives- Provides understanding on the different hallmarks of aging and how they can be applied in the development of anti-aging drugs- Discusses various anti-aging strategies, including telomerase reactivation, clearance of senescent cells, stem cell-based therapy, and others
Table of Contents
1. The aging: introduction, theories, principles and future prospectiveShabnam Shabir, Mahendra Pratap Singh2. Brief description of aging in different levels as cellular, tissues, and organsAnuradha Venkatakrishnan Chimata, Prajakta Deshpande, Amit Singh3. Brief about hallmarks of agingJosephine Esposto and Vyshnavy Balendra4. Overview of various anti-aging strategiesDhiraj Kumar and Faiyaz Ahmad5. Elimination of damaged cells-dependent anti-aging strategyRayees Ahmad Naik, Vinodinee Dubey, Roshni Rajpoot, Debabrata Dash, Nidhi Gupta and Raj Kumar Koiri6. Telomerase reactivation for anti-agingTS Gopenath, Shreya Shreshtha and Kanthesh M. Basalingapa7. Epigenetic drugs based on anti-aging approachTarun Minocha, Namrata Dwivedi, Chetan Panda, Anamika Misra, Barsha Baisakhi Nayak, Sanjeev Kumar Yadav, Hareram Birla and Sandeep K. Singh8. Activation of chaperons and proteolytic system: emerging methods for anti-aging drug developmentNeha Gogia, Victor Olmos, Fatema Haidery, Kimberly Luttik, Leon Tejwani, Janghoo Lim 9. Dietary restriction and mTOR and IIS inhibition: the potential to anti-aging drug approachSing-Hua Tsou10. Anti-Aging Drugs, Candidates, and Food Supplements- The journey so farYodhaanjali JR, Rithwick Surya, Sumukha KC, Harini G, Gouri Deshpande, Chandan S,Raghu Ram Achar11. Role of AMPK and Sirtuins as anti-aging proteinsManjula Ramu, Sonali Vishal and Neha Gogia12. Mitophagy and Mitohormetics: promising anti- aging strategyChih Li Lin13. Clearance of senescent cells: potent anti-aging approachJacques Ferreira and Alex Deamer14. Stem cell-based therapy as antiaging prospectiveSumaira Yusuf, Mahendra P. Singh15. Anti-inflammatory therapy as a game changer towards anti-agingDr. Naveen Shivavedi, Anshul Shakya, Bedanta Bhattacharjee and Bhargab Deka16. Invertebrate model organisms for aging researchArvind Kumar Shukla, Andrew Scott and Edward Giniger
