Proteostasis and Proteolysis

著者名：Chondrogianni, Niki (EDT)/Pick, Elah (EDT)/Gioran, Anna (EDT)

CRC Press（2021/11/30発売）

• 言語：ENG
• ISBN：9780367499334
• eISBN：9781000474596

Description

Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.

Chapter 2 of this book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license. 

Table of Contents

Preface

Contributors

The Editors

1. Ribosomal Pauses during Translation and Proteostasis

Alejandro Ferrando, Alihamze Fathinajafabadi, Arantxa Martínez- Férriz and Rosa Farràs

2. Protein Folding and Misfolding: Deciphering Mechanisms of Age-Related Diseases

Judith-Elisabeth Riemer, Diana Panfilova, Heidi Olzscha

3. Transcriptional Regulation of Proteostatic Mechanisms

Marianna Kapetanou, Sophia Athanasopoulou, Efstathios S. Gonos

4. MicroRNAs as Central Regulators of Adult Myogenesis and Proteostasis Loss in Skeletal Muscle Aging

Ioannis Kanakis, Ioanna Myrtziou, Aphrodite Vasilaki, Katarzyna Goljanek-Whysall

5. mRNA Granules and Proteostasis in Aging and Age-Related Diseases

Fivos Borbolis and Popi Syntichaki

6. Phospholipids and the Unfolded Protein Response

Ilias Gkikas and Nektarios Tavernarakis

7. Ubiquitin Ligases Involved in Progeroid Syndromes and Age-Associated Pathologies

Lisa Fechtner and Thorsten Pfirrmann

8. Role of SUMOylation in Neurodegenerative Diseases and Inflammation

Esmeralda Parra-Peralbo, Veronica Muratore, Orhi Barroso-Gomila, Ana Talamillo, James D. Sutherland and Rosa Barrio

9. NEDD8 and Oxidative Stress

Elah Pick and Giovanna Serino

10. Structure, Function and Regulators of the 20S Proteasome

Tobias Jung and Annika Höhn

11. Cellular Responses to Proteasome Impairment

Maja Studencka-Turski and Elke Krüger

12. Proteasome Fate in Aging and Proteinopathies

Mary A. Vasilopoulou, Nikoletta Papaevgeniou and Niki Chondrogianni

13. The Proteasomal System in Cancer

Sema Arslan-Eseryel, Ulkugul Guven and Betul Karademir-Yilmaz

14. Proteostasis and Skin Aging

Anne-Laure Bulteau and Bertrand Friguet

15. Reactive Oxygen Species and Protein Homeostasis in Skeletal Muscle Regeneration

Sofia Lourenço dos Santos, Aurore L’Honoré and Isabelle Petropoulos

16. Protein Degradation in Cardiac Health and Disease

Xuejun Wang

17. Autophagy in Aging and Oxidative Stress

Dimitra Ranti, Anna Gioran and Niki Chondrogianni

18. Autophagy in Aging and Longevity Exemplified by the Aging Heart

Steffen Häseli and Christiane Ott

Index