Description
Translational Autoimmunity: Etiology of Autoimmune Diseases is the first volume of the Translational Immunology book series. To attain its purpose as a detailed translational step to tackle autoimmunity, this volume sufficiently addresses basic questions on how the immune system is designed to distinguish self from nonself. It discusses the known mechanisms that lead to the maintenance of self-tolerance, presents potential triggers and malfunctions that impede normal immune processes, and demonstrates how the immune system induces an autoreactive state that results in the recognition of self-antigens seen in autoimmune conditions.- Includes coverage of basic immunology, the clinical aspects of autoimmunity, and translational immunology studies in autoimmunity- Presents key concepts supported by a systematic appraisal of the most recent evidence- Assists students at all the academic levels while also being applicable to scientists who work with autoimmunity- Designed for learning, teaching, review, testing, practice and research
Table of Contents
1. Introduction on translational autoimmunity: From bench to bedside2. Autophagy in autoimmunity3. Immunometabolism and autoimmunity4. T cell recognition of neo-epitopes in autoimmunity5. Role of Th1 and Th2 in autoimmunity6. Role of Th17 cell in tissue inflammation and organ-specific autoimmunity7. Peptide editing and its modulation in CD4+ T cell immune tolerance8. Innate lymphoid cells (ILCs) in the immunopathogenesis of autoimmune diseases9. Autoimmune diseases and the role of toll-like receptor-7 and -9 signaling cascades10. Association between type III interferons and systemic autoimmune diseases11. Regulation of immunological tolerance by NF-kB12. Micro RNA, circular RNA, neutrophils and myeloperoxydases in autoimmune diseases13. Human leukocyte antigen and autoimmunity14. HLA-G-mediated immunological tolerance and autoimmunity15. The immune system and the microbiota: the two sides of mucosal tolerance16. Role of free radicals in autoimmune disorders17. Immunological tolerance and autoimmunity18. Construction of bioscore for sprouting of self-tolerance failure: From analysis of silicosis cases
