Description
Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience of Development is a comprehensive reference on the diagnosis and management of neurodevelopment and associated disorders. This book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of development-related conditions.
Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with proper and abnormal development. This book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurodevelopment. It also examines in vitro and in vivo modelling of development with stem cells and model systems.
Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience Of Development:
- Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of development
- Features sections on diagnosis and biomarkers
- Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
- Focuses on neurodevelopmental disorders and environmental factors that influence neural development
- Includes more than 500 illustrations and tables
Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet:
- Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of development
- Features sections on the genetics of developmental conditions and accompanying behavior
- Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
- Focuses on neurodevelopmental disorders and environmental factors that influence neural development
- Includes more than 500 illustrations and tables
Table of Contents
Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience Of Development:
I. Introductory Chapters: Setting The Scene For The Neuroscience Of Development 1. The brain and its structures: an overview; 2. Neural tube defects: embryonic origin, clinical features and cell survival equilibrium impact; 3. Chemical substances affecting neurodevelopment; 4. High-risk babies and Neurodevelopmental outcome; 5. Genomic Imprinting and neurodevelopment; 6. Insights from model systems: Alcohol, neurodevelopment and zebrafish; 7. Early life nutrition and brain development: maternal iodine nutrition and neurodevelopment; 8. Endocrine Aspects of Development. Thyroid hormone actions in neurological processes during brain development
II. Impairments and Diseases 9. Pediatric brain tumors; 10. Neurofibromatosis Type 1: from cellular phenotypes to human brain function; 11. The role and development of neural crest cells; 12. Spina Bifida: A Biopsychosocial Perspective; 13. Diabetic ketoacidosis and neurodevelopment; 14. Four-dimensional features of fetal brain: applications to diabetes; 15. Prenatally exposed to nicotine and neurodevelopment; 16. Maternal methamphetamine and impact on the brain; 17. Alcohol, cannabis and brain development; 18. The Environmental Pollutant Trichloroethylene Disrupts Key Neural Pathways During Brain Development; 19. Developmental neurotoxicity of the herbicide atrazine; 20. Neurodevelopmental delays and in utero hyperemesis gravidarum; 21. Neurodevelopment and Infantile Epileptic Encephalopathy-9 (EIEE9); 22. Neurodevelopment in Turner syndrome; 23. Very preterm children and the impact on neurodevelopmental outcomes; 24. Linking congenital heart disease and brain functional connectivity in newborns; 25. Brain Growth in Congenital Heart Disease from Prenatal Environment to Adulthood; 26. Linking dopamine, amphetamine and neurodevelopment; 27. Developmental coordination disorder
III. Biomarkers, Screening, Methods and Diagnosis 28. Neurodevelopment and the The Ages and Stages Questionnaire, third edition (ASQ-3); 29. Screening for Attention Deficit Hyperactivity Disorder in children; 30. The Mini-Mental State Pediatric Examination screening tool: Italian perspectives; 31. Predictors of neurodevelopment in preterm infants: from the neonatal intensive care unit into adulthood; 32. The antenatal fetal neurodevelopmental test: uses and applications
IV: Management and Treatments 33. Pain, evaluation and management in neurodevelopmental conditions; 34. Use of levetiracetam: Features and applications to neonatal seizures; 35. Quetiapine treatment in paediatric scenarios; 36. Treatments with cannabinoids and brain development; 37. Pediatric dystonia and deep brain stimulation; 38. Use of repetitive transcranial magnetic stimulation in neurodevelopment: a narrative review; 39. Cognitive behavioral therapy in children with anxiety disorders; 40. Cognitive behavioral therapy for anxiety in children with autism spectrum disorder; 41. Nutritional treatment in fetal alcohol spectrum disorder; 42. Nurturing the Developing Brain to Reduce Neurological Delay; 43. Normalizing perinatal neurological development via intervention
V. Models And Modelling 44. Microplatforms as a Model for Neurological Conditions; 45. Disease models in neurodevelopmental disorders; 46. Endosulfan and impact on neurodevelopment: modelling with zebrafish (Danio rerio); 47. Neurodevelopment of the zebrafish spinal serotonin system; 48. Inbred mouse model of brain development and intestinal microbiota; 49. The myelin mutant taiep rat as a model of developmental disorder; 50. The MAM-E17 neurodevelopmental model of schizophrenia
VI. Resources 51. Research and recommended resources in the neuroscience of development Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet: I. Genetics, Molecular and Celluar Biology 1. Hereditary motor neuropathies; 2. Dopamine transporter (DAT1) polymorphism and development; 3. Genome wide association studies (GWAS) and neurodevelopment: Autism spectrum disorder; 4. SNPs and cerebral palsy; 5. Epigenetic regulation of cortical neurogenesis; 6. Functions and dynamics of axonal mitochondria; 7. Linking apoptosis and caspases in fetal neural tube defects; 8. Brain oxidative stress in Down syndrome; 9. Linking Adhesion GPCRs to Glial Cell Development and Function; 10. Immunoglobulin cell adhesion molecule superfamily and neurodevelopment; 11. Brain-derived neurotrophic factor (BDNF) and neurogenesis; 12. slc7a5 and neural development; 13. Linking SOX3, SRY and disorders of neurodevelopment; 14. Neuronal Src-homology-2 (SH2)B adaptor protein-1 (Sh2b1) and brain growth; 15. Effects of extrinsic factors and intracellular signalling and transcription factors regulating the development and cell fate of spinal cord ependymal cells; 16. Signaling molecules controlling oligodendrocyte development and brain myelination
II. Neurological and Imaging Features 17. Fetal brain structures: imaging oriented; 18. Four-dimensional (4D) ultrasonography: Methods, uses and fetal neuroscience; 19. Linking histology and neurological development of the fetal and infant brain; 20. Development of Corticospinal tract axons: from embryonic stage to adulthood; 21. Vascular endothelial growth factor (VEGF) and neurodevelopment; 22. Brain-wide connectivity architecture: developmental aspects; 23. Development and pathology of the germinal matrix; 24. Development of the GABAergic network in the mouse spinal cord; 25. Postnatal development, electrophysiology and sensory sural nerves; 26. Neuroscience of the developing axonal strata in the human fetal brain; 27. Neuroactive steroids and neurodevelopment; 28. Voltage and ligand-gated ion channels appearance and function in neurodevelopment; 29. Features of brain development over 13 years in preterms; 30. The medial pulvinar in neurodevelopment; 31. Cortical sulci in the human fetal brain and development; 32. The prenatal development of the human cerebellum; 33. Developing cerebello-cerebral connectivity in health and disease: a focus on epilepsy; 34. Prenatal exposure to progestins: impact on neurodevelopment of the child
III. Physiological Aspects 35. Brain lesion characteristics in relation to upper limb function in children with unilateral cerebral palsy; 36. Maternal exercise and brain development; 37. Pyramidal neurons: physiology, Pathophysiology and postnatal development; 38. Working memory: physiology and neurodevelopment; 39. EEG development in resting states; 40. Availability and metabolism of thyroid hormones in the developing brain
IV. Behavior And Psychopathological Aspects 41. Psychosocial issues and quality of life following childhood stroke; 42. Neuropsychological function following childhood stroke; 43. Youths with autism and working memory; 44. Linking the mesial temporal lobe, 3D probabilistic maps and development; 45. Cognitive aspects of Down Syndrome; 46. Adolescent cannabis use and neurocognitive development; 47. The Role of Social Anxiety in Autism and the Broader Autism Phenotype: Evidence from Childhood through Adulthood; 48. Impact of touch on bonding and neurodevelopment; 49. Neurobehaviour and catch up growth
V. Diet And Nutrition 50. Caloric restriction and the developing brain; 51. High-fat diet, tryptophan hydroxylase-2 mRNA expression and neurodevelopment; 52. Bone mineral density and nutritional status in children with cerebral palsy; 53. Epigallocatechin-3-gallate: linking the neurogenesis, hippocampus and Down syndrome; 54. Folic acid-to prevent spina bifida and anencephaly
