Description
**Selected for Doody's Core Titles® 2024 in Endocrinology/Metabolic Disease**Updated with new and expanded chapters, Endocrine Disruption and Human Health, Second Edition provides an introduction to what endocrine disruptors are, the issues surrounding them, the source of these chemicals in the ecosystem and the mechanisms of action and assay systems. Contributions by specialists are included to discuss the varying effects of endocrine disruption on human health, and procedures for risk assessment of endocrine disruptors, and current approaches to their regulation are also covered.With new material on topics such as low-term, low dose mixtures, windows of susceptibility, epigenetics, EDCs effect on the gut microbiome, EDCs in from polluted air and oral exposures, green chemistry, and nanotechnology, the new edition of Endocrine Disruption and Human Health is a valuable and informative text for academic and clinical researchers and other health professionals approaching endocrine disruption and its effects on human health for the first time, graduate students, and advanced undergraduate students.- Provides readers with access to a range of information from the basic mechanisms and assays through to cutting-edge research investigating concerns for human health- Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health- Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations- Newly added content on topics like low-term, low dose mixtures, windows of susceptibility to EDCs, EDCs effect on the gut microbiome, green chemistry, and nanotechnology
Table of Contents
SECTION 1 OVERVIEW and SCOPE1. What is endocrine disruption?2. Which chemicals are endocrine disruptors?SECTION 2 MECHANISMS and ASSAY SYSTEMS3. Environmental oestrogens: Disrupters of oestrogen action4. Disrupters of androgen action5. Assay systems for studying endocrine disruption6. Non-monotonic responses in endocrine disruption7. Endocrine disrupters as modifiers of endogenous hormone synthesisSECTION 3 CONCERNS FOR HUMAN HEALTH8. Endocrine disruption and female reproductive health9. Endocrine disruption and breast cancer10. Endocrine disruption and male reproductive health11. Endocrine disruption and prostate cancer12. Endocrine disruption and thyroid disease13. Endocrine disruption of adrenal function14. Endocrine disruption of developmental pathways and children's health15. Endocrine disruption of immune function16. Endocrine disruption and obesity, metabolic syndrome and type 2 diabetes17. Endocrine disruption and cardiovascular disease18. Transgenerational effects of endocrine disruption19. Regulatory considerations
