Description
Overcoming Drug Resistance in Gynecologic Cancers provides up-to-date information related to important gynecologic cancers and focuses on mechanisms of drug resistance, genetics, signaling, immunology, health disparities, nanotechnology, economic considerations and financial impacts. The book covers not only drug resistance but also important means to reverse resistance both in the laboratory and clinic. The book discusses topics such as lifestyle, nutrition and risk of gynecologic cancers, the financial impact of drug resistance, chemosensitizing agents and targeted therapies in cervical, endometrial and ovarian cancer, immunotherapy to overcome drug resistance, and genetic polymorphisms in gynecologic cancers.Additionally, it discusses ethnic and racial health disparity perspectives and future developments in chemosensitizing activities to reverse drug resistance in gynecologic cancers. It is a valuable resource for cancer researchers, oncologists, clinicians and other biomedical field members who are interested in new approaches to improve chemotherapy outcome in patients with gynecologic cancers.- Provides a comprehensive resource with all the details needed for readers to understand and follow information- Encompasses schematics, diagrams and flow charts in all chapters to help readers easily follow critical information- Presents tables and figures especially developed to summarize the information with appropriate statistical rigor and to show details of clinical specimens such as pathological, radiological characteristics, and/or laboratory biomarkers
Table of Contents
1. Introduction to gynecologic cancers: An emphasis on pathogenesis, incidence sand diagnosis2. Lifestyle, nutrition, and risk of gynecologic cancers3. Drug Resistance in Gynecologic Cancers: Findings and Underlying Mechanisms4. Mechanisms of Chemo-resistance and Approaches to Overcome its Impact in Gynecologic Cancers5. Drug resistance in gynecologic cancers: Findings and underlying mechanismsCurrent Treatment Modalities in Major Gynecologic Cancers: Emphasis on Response Rates6. Drug Resistance in Gynecologic Cancers: Emphasis on Non-coding RNAs and Drug Efflux Mechanisms7. Genetic Polymorphisms in Gynecologic Cancers8. Overcoming Drug Resistance in Cervical Cancer: Chemo-sensitizing Agents and Targeted Therapies9. Immune Response, Inflammation Pathway Gene Polymorphisms and the Risk of Cervical Cancer10. Overcoming Chemotherapy Resistance in Endometrial Cancer11. Chemoresistance in Uterine Cancer: Mechanisms of Resistance and Current Therapies12. Ovarian Cancer: Targeted Therapies and Mechanisms of Resistance13. Overcoming Drug Resistance in Ovarian Cancer: Chemo-sensitizing Agents, Targeted Therapies14. Resistance to Chemotherapy Among Ethnic and Racial Groups: Health Disparities Perspective in Gynecologic Cancers15. Future Perspectives and New Directions in Chemosensitizing Activities to Reverse Drug Resistance in Gynecologic Cancers: Emphasis on Challenges and Opportunities
