A Hidden Legacy : The Life and Work of Esther Zimmer Lederberg

著者名：Schindler, Thomas E.

Oxford University Press（2021/08/17発売）

• 言語：ENG
• ISBN：9780197531679
• eISBN：9780197531693

Description

It's time to honor the significant scientific contributions of Esther Zimmer Lederberg. In A Hidden Legacy, Thomas E. Schindler shares the story of this remarkable microbiologist and offers insight into why her legacy has been obscured for so long.In the mid-20th century, microbiologist Esther Zimmer Lederberg and her then-husband, Joshua Lederberg, made a series of remarkable discoveries that contributed to the biochemical understanding of the gene. Together, they laid the foundation for molecular biology and the field of bacterial genetics. In 1958, he alone was awarded the Nobel Prize for their work. Esther's ingenuity was largely ignored and undervalued by the Nobel committee and has continued to be obscured by historians of science.In this book, Thomas E. Schindler shares many of Esther's hidden scientific contributions and her role in the discoveries that launched her then-husband's celebrated career. A Hidden Legacy delves into how, as a couple, the Lederbergs established a new field of bacterial genetics in the decade leading up to the discovery of the DNA double helix. Their impressive series of achievements includes the discovery of: *l bacteriophage and the first plasmid, known as the F-factor; how viruses carry bacterial genes between bacteria; and fundamental properties of bacterial sex. Schindler explains how Esther's research revealed unique features of bacterial sex that are now essential to our understanding of molecular biology and evolution.A magnificent story of a remarkable scientist, A Hidden Legacy takes readers through the process that scrambled the tree of life and offers insight into the role Esther played in uncovering these secretes of bacterial and viral genes.

Table of Contents

IntroductionChapter 1: An Abiding AffectionChapter 2: The Pathway to Bacterial GeneticsChapter 3: Graduate School: Mentored by the Future Nobel Laureates, George Beadle and Edward TatumChapter 4: The Anomaly of Bacterial GeneticsChapter 5: Love in the Laboratory: A Marriage of Two ProdigiesChapter 6: Strange Genetics: Bacterial Genes Move SidewaysChapter 7: Clarifying the Unique Features of Bacterial SexChapter 8: Replica Plating: Esther Repurposes Her Compact Makeup SpongeChapter 9: The Matilda Effect: Joshua Lederberg's Brilliance Obscured His Wife's ReputationChapter 10: What She Did for Love: Demoted from Research Collaborator to Nobel WifeChapter 11: Behind the Laboratory Doors: For Over One Hundred Years of Science, Women Participated in ObscurityChapter 12: Antibiotic Resistance, the Horrendous Consequences of Bacterial SexChapter 13: The Lederbergs' Stanford Years, 1959-1976: Growing Apart, the Collaborative Couple DivorceChapter 14: The Central Importance of E. coli and λ Phage in the New Molecular BiologyChapter 15: Making Music and a New LifeEpilogue: A New Tree of Life and a New Concept for the GeneAcknowledgmentsIndex