Description
Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span.This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described.Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies.- Contains detailed information on mitochondrial dysfunction- Reviews our current understanding of the role of mitochondria in aging- Includes coverage of specific conditions, including sports and affective disorders, among others- Discusses mitochondria targeted delivery of therapeutic compounds
Table of Contents
Part I - Mitochondrial Dysfunction1. Mitochondrial dysfunction and affective disorders: Focus on diet, exercise, and aging2. Mitochondrial dysfunction in inborn errors of metabolism3. Impaired mitochondrial dynamics in disease4. Mitochondrial dysfunction in metabolic disorders5. Mitochondrial dysfunction and autophagy in neurodegenerationin neurodegeneration6. Mitochondrial dysfunction in sepsis7. Drug or toxin induced mitochondrial toxicity8. Aging, mitochondria, and autophagy9. Skin aging and mitochondriaPart II - Strategies utilized to deliver natural molecules to the mitochondria10. Organelle targeting: focus on the mitochondria11. Nanotechnology, mitochondria, and cancer12. Nanomaterials aimed towards the cardiac mitochondria: of therapeutics to nanosafety13. Increasing resveratrol bioavailability: a therapeutic challenge focusing on the mitochondria14. Advances in nanotechnology-related strategies against melanoma15. Challenges in the delivery of polyphenols to cancer cells16. Challenges in the nanoscale delivery systems development in the pharmaceutical and nutraceutical markets17. Therapeutic implications of targeting antioxidants to the mitochondria18. Nanomedicines and phytochemicals targeting Alzheimer's Disease19. Mitochondria-targeted drugs and immune function20. Polymeric Drug Delivery Systems for Mitigating Oxidative Stress21. Polyphenols and the Microbiota: A Challenge in Mitochondrial Therapy
