Description
Direct Nose-to-Brain Drug Delivery provides the reader with precise knowledge about the strategies and approaches for enhanced nose-to-brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration and includes an overview on the toxicity aspects of the various materials used to develop the direct nose-to-brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. This book is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems and novel drug administration devices for the treatment of neuro-ailments.- Explains the targeting approaches for enhanced brain targeting following intranasal drug administration- Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose-to-brain- Discusses pharmaceutical and biomedical applications after nose-to-brain delivery of therapeutic pharmaceuticals and biologicals
Table of Contents
Section I Basic considerations in nose-to-brain drug delivery1. An overview of anatomical and physiological aspects of the nose and the brainDignesh Khunt and Manju Misra2. Direct transport theory: From the nose to the brainNamdev Dhas, Dattatray Yadav, Ashutosh Singh, Atul Garkal, Ritu Kudarha, Priyanka Bangar, Jignasa Savjani, Chandrakantsing V. Pardeshi, Neha Garg, and Tejal Mehta3. Physicochemical, biopharmaceutical, and practical considerations for efficient nose-to-brain drug deliveryUmesh D. Laddha and Amol A. TagalpallewarSection II Nanotechnology and naso-brain drug delivery4. Nanomedicines for CNS therapy: Fundamental aspectsDrashti Desai, Bala Prabhakar, and Pravin Shende5. Nanotechnological advances in direct nose-to-brain drug delivery for neurodegenerative disorders and other neuroailmentsRahul Shukla, Ashish Kumar, and S.J.S. Flora6. Surface modification of nanocarriers as a strategy to enhance the direct nose-to-brain drug deliveryChandrakantsing V. Pardeshi and Eliana B. Souto7. Mucoadhesion as a strategy to enhance the direct nose-to-brain drug deliveryMrunal Patil8. Nanoparticles for direct nose-to-brain drug delivery: Implications of targeting approachesRaju O. Sonawane, Yogeshwar Bachhav, Avinash R. Tekade, and Chandrakantsing V. Pardeshi9. Strategies for enhanced direct nose-to-brain drug deliveryYamini Madav and Sarika WairkarSection III Carriers for direct nose-to-brain drug delivery10. Particulate carriers for nose-to-brain deliveryShiv Bahadur and Kamla Pathak11. Vesicular carriers for direct nose-to-brain drug deliveryPrashant K. Deshmukh, Swapnil N. Jain, Pravin O. Patil, and Chandrakantsing V. Pardeshi12. Gel-based delivery of neurotherapeutics via naso-brain pathwaysHitendra S. Mahajan and Payal H. PatilSection IV Applications of direct nose-to-brain delivery13. Applications of direct nose-to-brain drug delivery in medicine and pharmacyGanesh B. Shevalkar, Mahendra K. Prajapati, Rohan V. Pai, and Kamlesh D. Mali14. Applications of direct nose-to-brain drug delivery in biomedicine, biotechnology, tissue engineering, and immunologySanjay B. Patil15. Diagnostic and theranostic intranasal nanointerventions for brain diseasesPrashant Upadhaya, Sreeranjini Pulakkat, and Vandana Patravale16. Nose-to-brain delivery of biologics and stem cellsMukta Agrawal, Aditya Narayan Konwar, Amit Alexander, and Vivek Borse17. Applications of nose-to-brain delivery in nanodiagnosis and nanotherapy of neurodegenerative disordersAbhijeet Kulkarni, Mahesh Shinde, Gaurav Sonawane, Hitesh Raotole, Rohit Pande, and Chandrakantsing V. Pardeshi18. Intranasal gene therapy for the treatment of neurological disordersNamdev Dhas, Tejal Mehta, Shilpa Sharma, Atul Garkal, Dattatray Yadav, Kartik Hariharan, Babeeta Shamjetshabam, Shubham Khot, Ritu Kudarha, Priyanka Bangar, Gajanan Arbade, and Pratap Kalyankar19. Potential of naso-brain drug delivery in glioblastoma therapyAmarjitsing Rajput, Nikunj Tandel, Swapnil Borse, and Shital Butani20. Nose-to-brain delivery of antiretroviral drugs against NeuroAIDSKailas K. Moravkar, Devanshi S. Shah, Durgesh K. Jha, Purnima D. Amin, and Sanjay J. SuranaSection V Technological advances for effective drug administration21. A technology overview on advanced drug administration devices for effective nose-to-brain deliverySadhana R. Shahi and Chandrakantsing V. PardeshiSection VI Evaluation of direct nose-to-brain drug delivery22. Experimental models for evaluation of direct nose-to-brain drug deliveryVinit V. Agnihotri, Ashish P. Gorle, Chandrakantsing V. Pardeshi, and Sanjay J. Surana23. Quantitative and qualitative analysis of direct nose-to-brain drug deliveryVeena S. Belgamwar, Vidyadevi T. Bhoyar, Sagar Trivedi, and Chandrakantsing V. PardeshiSection VII Toxicity and regulatory aspects24. Toxicity aspects: Crucial obstacles to clinical translation of nanomedicinesVikas Bansal, Sameer S. Katiyar, and Chander Parkash Dora25.
