Description
Gastroparesis: Pathophysiology, Clinical Presentation, Diagnosis and Treatment is a reference book providing a centralized source of data on gastroparesis collected over the last decade. Contents include the pathophysiology, clinical presentation, diagnostic recommendations and treatment options for gastroparesis. The reference is split into broad subsections, with the strategy of first focusing on the key features of the disease and then turning to controversies, recent developments, patient support resources, the spectrum of treatment – including medical and surgical - and future directions.
Chapters will include coverage of important topics like autonomic neuropathy, the brain-gut axis, potential pathophysiological advances at the cellular level, diagnostic and therapeutic options specifically targeted at the pylorus, and the evaluation of the female predominance in gastroparesis. This is a must-have resource for scientists looking to find the next step in their research as well as healthcare professionals ranging from Gastroenterologists to Internists, Surgeons, Nutritionists, Psychiatrists, and Psychologists, Residents and Medical Students who struggle with how to optimally take care of their gastroparetic patients.
- Provides a comprehensive overview of what is known regarding the pathophysiology, clinical presentation, diagnostic considerations and treatment options for gastroparesis
- Includes key updates made in the last decade, including the progress made by the NIH Gastroparesis Consortium
- Presents both sides of key controversies in the field, including the debate between classification of gastroparesis versus functional dyspepsia
- Fully reviews the major advances in pharmacologic agents for therapy, both anti-emetics and prokinetics
- Extensive update on the "Pyloric Revolution" and our understanding of the pathophysiology of gastroparesis and how the focus on the pylorus has literally transformed our treatment strategy with an emphasis on both surgical and endoscopic advances in addressing pyloric dysfunction
Table of Contents
I. Introduction & clinical presentation 1. Historical perspectives on gastric motility and gastroparesis 2. Epidemiology of gastroparesis 3. Clinical presentations of gastroparesis 4. Natural history of patients with gastroparesis
II. Pathophysiology 5. Gastric dysmotility at the organ level in gastroparesis 6. Cellular pathogenesis of gastroparesis 7. Sensory dysfunction in gastroparesis 8. Pathology of gastroparesis: ICC, enteric neurons and fibrosis 9. Gastroparesis and the brain-gut axis 10. Autonomic neuropathies and gastroparesis
III. Diagnostic considerations 11. Gastric emptying scintigraphy 12. The use of wireless motility capsule in the diagnosis and monitoring of gastroparesis 13. Breath tests for the assessment of gastroparesis 14. Magnetic resonance imaging for gastric motility and function 15. Electrogastrography for suspected gastroparesis 16. Antroduodenal manometry for the evaluation of patients with suspected gastroparesis 17. Ancillary testing including barostat, SPECT, and satiety testing
IV. Clinical subsets 18. Diabetic gastroparesis 19. Postsurgical gastroparesis 20. Idiopathic gastroparesis 21. Gastroparesis from other causes 22. Pediatric gastroparesis
V. Therapeutic considerations 23. Dietary therapy for gastroparesis 24. Prokinetic agents for gastroparesis 25. Antiemetic therapy for gastroparesis 26. Abdominal pain in gastroparesis: Prevalence, potential causes and management 27. Psychiatric aspects of gastroparesis 28. Alternative, complementary medicine and cannabinoids for gastroparesis 29. Enteric tube placement for gastroparesis: Gastrostomy, gastrojejunostomy and jejunostomy 30. Gastric electrical stimulation for gastroparesis 31. Surgical management of gastroparesis
VI. Controversies & new developments 32. Studies from the NIH Gastroparesis Clinical Research Consortium: Towards improving our understanding and treatment of gastroparesis 33. Evaluating response in gastroparesis: Patient reported outcome measures and survey 34. The pyloric revolution: Patient selection 35. Endoscopic full-thickness gastric biopsy: Ready for prime time? 36. Distinguishing between functional dyspepsia and gastroparesis: Does it matter? 37. Female predominance in gastroparesis 38. A brief history and future directions of permanent, temporary, and endoscopic GES 39. Cell transplantation for gastroparesis 40. A vision of the future for gastroparesis 41. Resources for the gastroparesis patient
