Description
Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer's disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.- Offers comprehensive coverage of a broad range of topics related to dementia- Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction- Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding- Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations- Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations- Serves as a "one-stop" source for everything you need to know about dementia
Table of Contents
Part I: Genetics, molecular and cellular biology1. The neuron navigator 2 gene and Alzheimer's diseaseChun Xu, Brenda Bin Su, Stephanie Lozano and Kesheng Wang2. Interlinking polymorphisms, estrogens, and Alzheimer diseaseLu Hua Chen, Leung Wing Chu and You-Qiang Song3. Linking EEGs, Alzheimer disease, and the phosphatidylinositol-binding clathrin assembly protein (PICALM) geneNatalya Ponomareva, Tatiana Andreeva, Vitaly Fokin, Sergey Illarioshkin and Evgeny Rogaev4. CD36 gene polymorphisms and Alzheimer's diseaseOmar Šerý, Nandu Goswami and Vladimir J. Balcar5. Genetic contributions to sporadic frontotemporal dementiaJessie S. Carr, Daniel W. Sirkis and Jennifer S. Yokoyama6. Clinical response to cholinesterase inhibitors in dementia: the role of CYP2D6 and APOE genetic polymorphismsLuís Felipe José Ravic de Miranda, Karina Braga Gomes and Paulo Caramelli7. A1 and A2 purinergic receptor expression in dementiaJ. Mendiola-Precoma, L.C. Berumen, A. Rodríguez-Cruz and G. García-Alcocer8. Molecular aspects of metallothioneins in dementiasGemma Comes, Anna Escrig, Yasmina Manso, Olaya Fernández-Gayol, Paula Sanchis, Amalia Molinero, Mercedes Giralt, Javier Carrasco and Juan Hidalgo9. Implication of microRNAs in Alzheimer's disease pathogenesisKatarzyn Marta Zoltowska, Katarzyna Laskowska-Kaszub, Siranjeevi Nagaraj and Urszula Wojda10. Role of cellular oxidative stress in dementiaGiovanna Galliciotti, Antonella De Jaco, Diego Sepulveda-Falla, Emanuela D'Acunto and Elena Miranda11. Toward an integrative understanding of the neuroinflammatory molecular milieu in Alzheimer disease neurodegenerationJuan M. Zolezzi, Paulina Villaseca and Nibaldo C. Inestrosa12. Wnt signaling and dementiaCarolina Alquezár and Ángeles Martín-Requero13. Linkage of atypical protein kinase C to Alzheimer diseaseRobert V. Farese and Mini P. Sajan14. Linking histone deacetylases and phosphodiesterase 5 in novel treatments for Alzheimer's diseaseAna Garcia-Osta and Mar Cuadrado-Tejedor15. Nuclear factor erythroid 2-related factor 2 in Alzheimer's diseaseKelsey E. Murphy and Joshua J. Park16. Implications of alpha- and beta-secretase expression and function in Alzheimer's diseaseSven Reinhardt and Kristina Endres17. Methylation analysis of DNA in Alzheimer's diseaseFabio Coppedè18. The signalosome malfunctions in age-associated neuropathologiesRicardo Puertas-Avendaño, David Quinto-Alemany, Miriam González-Gómez and Raquel Marin19. FAM3C in Alzheimer's disease: a risk-related molecule and potential therapeutic targetMasaki Nishimura, Naoki Watanabe, Emi Hibino, Masaki Nakano, Yachiyo Mitsuishi, Lei Liu and Takuma Sugi20. Amylin and amylin receptors in Alzheimer's diseaseWen Fu and Jack H. Jhamandas21. Mammalian target of rapamycin complexes: regulation and Alzheimer's diseaseHenry Querfurth and Han-Kyu Lee22. Mammalian target of rapamycin complexes: protein synthesis and autophagy, Parkinson's disease, amyotrophic lateral sclerosis, and frontotemporal dementiaHenry Querfurth and Han-Kyu Lee23. Linking CD200 in brains and dementia: molecular aspects of neuroinflammationDouglas Gordon WalkerPart II: Neurological, physiological and imaging24. Hippocampal atrophy associated with dementia risk factors and dementiaHiroshi Yao, Yuko Araki, Fumio Yamashita, Makoto Sasaki and Manabu Hashimoto25. Inflammation and insulin resistance in Alzheimer's disease: partners in crimeYuval Nash and Dan Frenke26. Brain susceptibility to hypoxia/hypoxemia and metabolic dysfunction in Alzheimer's disease: insights from animal and in vitro modelsVito Antonio Baldassarro, Andrea Bighinati, Michele Sannia, Luciana Giardino and Laura Calzà27. Neuropeptides and neurolipids: what they are and how they relate to Alzheimer's diseaseIván Manuel, Laura Lombardero, Alberto Llorente-Ovejero and Rafael Rodríguez-Puertas28.
