Description
Through 10 outstanding editions, Kelley & Firestein’s Textbook of Rheumatology has provided authoritative, in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. The 11th Edition of this classic text continues this tradition of excellence, while keeping you abreast of recent advances in genetics and the microbiome, new therapies such as biologics and biosimilars, and other rapid changes in the field. It provides comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, in a user-friendly, full color reference.
- Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes—including key data on therapeutic outcomes to better inform clinical decision making.
- Includes new chapters on Innate Lymphoid Cells and Natural Killer Cells, Pathogenesis of Inflammasome Mediated Diseases, Bisphosphonates, Ultrasound Evaluation of the Musculoskeletal System, and Evaluation of Monoarticular and Polyarticular Arthritis.
- Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs.
- Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editor Dr. Gary Koretzky, specialist in immunology and rheumatology.
- Demonstrates the complete musculoskeletal exam in online videos , including abnormal findings and the arthroscopic presentation of diseased joints.
Table of Contents
VOLUME I
Part 1: Structure and Function of Bone, Joints, and Connective Tissue
1. Biology of the Normal Joint, 1 Carla R. Scanzello and Steven R. Goldring
2. Synovium, 20 Douglas J. Veale and Gary S. Firestein
3. Cartilage and Chondrocytes, 34 Ali Mobasheri, Mary B. Goldring, and Richard F. Loeser
4. Biology, Physiology, and Morphology of Bone, 60 Aline Bozec, Anika Grüneboom, and Georg Schett
5. Muscle: Anatomy, Physiology, and Biochemistry, 67 Mark S. Miller, Edward P. Debold, and Michael J. Toth
6. Biomechanics, 80 Kenton R. Kaufman and KaiNan An
7. Regenerative Medicine and Tissue Engineering, 92 Frank P. Luyten, Cosimo De Bari, and Francesco Dell’Accio
8. Proteinases and Matrix Degradation, 109 Yoshifumi Itoh
Part 2: Cells Involved in Autoimmune Diseases and Inflammation
9. Dendritic Cells, 132 Mansi Saxena, Nicolas Vabret, Luciana Ribeiro Muniz, and Nina Bhardwaj
10. Mononuclear Phagocytes, 149 Deborah R. Winter, Anna Montgomery, and Harris Perlman
11. Neutrophils, 161 Binita Shah, Nathalie Burg, and Michael H. Pillinger
12. T Lymphocytes, 182 Ralph C. Budd
13. B Cells, 199 Yong-Rui Zou, Christine Grimaldi, and Betty Diamond
14. Fibroblasts and Fibroblast-like Synoviocytes, 222 Christopher D. Buckley and Andrew Filer
15. Mast Cells, 241 Peter A. Nigrovic
16. Innate Lymphoid Cells and Natural Killer Cells, 254 Michael A. Paley and Wayne M. Yokoyama
17. Platelets and Megakaryocytes, 262 Eric Boilard and Peter A. Nigrovic
Part 3: Effector Mechanisms in Autoimmunity and Inflammation
18. Principles of Signaling, 273 Abel Suarez-Fueyo, Vaishali R. Moulton, and George C. Tsokos
19. The Immunologic Repercussions of Cell Death, 286 Helen M. Beere and Douglas R. Green
20. Innate Immunity, 306 Gregoire Lauvau and Steven A. Porcelli
21. Adaptive Immunity, 320 Martha S. Jordan and Gary A. Koretzky
22. Autoimmunity and Tolerance, 337 Dwight H. Kono and Argyrios N. Theofilopoulos
23. The Microbiome in Health and Disease, 355 Rob Knight
24. Metabolic Regulation of Immunity, 368 Ruoning Wang, Tingting Wang, and Stephen Tait
25. Genetics of Rheumatic Diseases, 378 Stephen Eyre and Anne Barton
26. Epigenetics of Rheumatic Diseases, 393 Amr H. Sawalha and Matlock A. Jeffries
27. Complement System, 409 V. Michael Holers and Leendert A. Trouw
28. Prostaglandins, Leukotrienes, and Related Compounds, 420 Robert B. Zurier
29. Chemokines and Cellular Recruitment, 437 Gerard Graham
30. Angiogenesis, 445 Ursula Fearon, Zoltán Szekanecz, and Douglas J. Veale
31. Cytokines, 455 Iain B. McInnes
32. Experimental Models for Rheumatoid Arthritis, 467 Rikard Holmdahl
33. Neuronal Regulation of Pain and Inflammation, 480 Camilla I. Svensson and Linda S. Sorkin
Part 4: Broad Issues in the Approach to Rheumatic Disease
34. Clinical Research Methods in Rheumatic Disease, 495 Jeffrey R. Curtis, Yvonne M. Golightly, and Kenneth G. Saag
35. Economic Impact of Arthritis and Rheumatic Conditions, 510 Louise B. Murphy
36. Assessment of Health Outcomes, 522 Dorcas E. Beaton, Maarten Boers, Peter Tugwell, and Lara Maxwell
37. Biomarkers in Rheumatology, 536 Michael J. Townsend, Saloumeh K. Fischer, and Andrew C. Chan
38. Occupational and Recreational Musculoskeletal Disorders, 551 Richard S. Panush
39. Cardiovascular Risk in Inflammatory Rheumatic Disease, 563 Cynthia S. Crowson, Sherine E. Gabriel, and Anne Grete Semb
40. Cancer Risk in Rheumatic Diseases, 579 Eric L. Matteson
41. Introduction to Physical Medicine and Rehabilitation, 592 Sara J. Cuccurullo, Jaclyn Joki, and Ofure Luke
42. Pregnancy and Rheumatic Diseases, 604 Lisa R. Sammaritano and Bonnie L. Bermas
Part 5: Evaluation of Generalized and Localized Symptoms
43. History and Physical Examination of the Musculoskeletal System, 621 John M. Davis III, Kevin G. Moder, and Gene G. Hunder
44. Ultrasound in Rheumatology, 638 Eugene Y. Kissin, Paul J. DeMarco, and Amy C. Cannella
45. Evaluation of Monoarticular and Polyarticular Arthritis, 663 Ronald F. van Vollenhoven
46. Skin and Rheumatic Diseases, 678 David F. Fiorentino and Victoria P. Werth
47. The Eye and Rheumatic Diseases, 702 James T. Rosenbaum
Part 6: Differential Diagnosis of Regional and Diffuse Musculoskeletal Pain
48. Neck Pain, 711 Jennifer Kosty, Rani Nasser, Raul A. Vasquez, Cyrus C. Wong, and Joseph S. Cheng
49. Shoulder Pain, 727 Scott David Martin and Thomas S. Thornhill
50. Low Back Pain, 753 Rajiv Dixit
51. Hip and Knee Pain, 776 James I. Huddleston, III, and Stuart Goodman
52. Foot and Ankle Pain, 792 Christopher P. Chiodo, Mark D. Price, and Adam P. Sangeorzan
53. Hand and Wrist Pain, 800 Kenneth W. Donohue, Felicity G. Fishman, and Carrie R. Swigart
54. Temporomandibular Joint Pain, 813 Daniel M. Laskin
55. Fibromyalgia, 825 Leslie J. Crofford
Part 7: Diagnostic Tests and Procedures in Rheumatic Diseases
56. Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology, 841 Hani S. El-Gabalawy and Stacy Tanner
57. Arthrocentesis and Injection of Joints and Soft Tissues, 859 Ahmed S. Zayat, Andrea di Matteo, and Richard J. Wakefield
58. Anti-nuclear Antibodies, 875 Stanford L. Peng and Joseph E. Craft
59. Autoantibodies in Rheumatoid Arthritis, 890 Erika Darrah, Antony Rosen, and Felipe Andrade
60. Acute Phase Reactants, 907 Rebecca Haberman, Cesar E. Fors Nieves, Bruce N. Cronstein, and Amit Saxena
61.Imaging in Rheumatic Diseases, 920 Mikkel Østergaard, Ho Jen, Jacob L. Jaremko, and Robert G.W. Lambert
Part 8: Pharmacology of Anti-rheumatic Drugs
62. Therapeutic Targeting of Prostanoids, 965 Leslie J. Crofford
63. Glucocorticoid Therapy, 985 Marlies C. van der Goes and Johannes W.G. Jacobs
64. Traditional DMARDs: Methotrexate, Lefl, Sulfasalazine, Hydroxychloroquine, and Combination Therapies, 1007 Amy C. Cannella and James R. O’Dell
65. Immunosuppressive Drugs, 1031 Jacob M. van Laar
66. Anti-cytokine Therapies, 1046 Katharine McCarthy, Arthur Kavanaugh, and Christopher T. Ritchlin
67. Cell-Targeted Biologics and Emerging Targets: Rituximab, Abatacept, and Other Biologics, 1068 Peter C. Taylor
68. Intra-cellular Targeting Agents in Rheumatic Disease, 1091 Virginia Reddy and Stanley Cohen
69. Urate-Lowering Therapy, 1111 Ted R. Mikuls
70. Bisphosphonates, 1125 Arthur C. Santora II and Kenneth G. Saag
71. Analgesic Agents in Rheumatic Disease, 1135 Gregory R. Polston and Mark S. Wallace
72. Nutrition and Rheumatic Diseases, 1156 Lisa K. Stamp and Leslie G. Cleland
73. Evaluation and Management of Early Undifferentiated Arthritis, 1173 Karim Raza
VOLUME II
Part 9: Rheumatoid Arthritis
74. Etiology of Rheumatoid Arthritis, 1181 Gary S. Firestein
75. Pathogenesis of Rheumatoid Arthritis, 1200 Gary S. Firestein
76. Clinical Features of Rheumatoid Arthritis, 1236 Bryant R. England and Ted R. Mikuls
77. Treatment of Rheumatoid Arthritis, 1258 James R. O’Dell
78. Sjögren’s Syndrome, 1284 E. William St. Clair and David L. Leverenz
Part 10: Spondyloarthritis
79. Etiology and Pathogenesis of Spondyloarthritis, 1307 Keith A. Sikora and Robert A. Colbert
80. Ankylosing Spondylitis and Other Forms of Axial Spondyloarthritis, 1319 Sjef van der Linden, Matthew Brown, Lianne S. Gensler, Tony Kenna, Walter P. Maksymowych, and William J. Taylor
81. Reactive Arthritis, 1344 John D. Carter and Alan P. Hudson
82. Psoriatic Arthritis, 1359 Oliver FitzGerald and Conor Magee
83. Inflammatory Bowel Disease–Associated Arthritis and Other Enteropathic Arthropathies, 1381 Richard Zamore, Meenakshi Bewtra, and Alexis Ogdie
Part 11: Systemic Lupus Erythematosus and Related Syndromes
84. Etiology and Pathogenesis of Systemic Lupus Erythematosus, 1396 Mary K. Crow
85. Clinical Features of Systemic Lupus Erythematosus, 1413 Maria Dall’Era and David Wofsy
86. Treatment of Systemic Lupus Erythematosus, 1437 Antonis Fanouriakis, George Bertsias, and Dimitrios T. Boumpas
87. Antiphospholipid Syndrome, 1460 Medha Barbhaiya, Jane E. Salmon, and Doruk Erkan
Part 12: Systemic Sclerosis, Inflammatory Myopathies, and Overlap Syndromes
88. Etiology and Pathogenesis of Systemic Sclerosis, 1473 John Varga
89. Clinical Features and Treatment of Scleroderma, 1499 Fredrick M. Wigley and Francesco Boin
90. Inflammatory Diseases of Muscle and Other Myopathies, 1539 Kanneboyina Nagaraju, Rohit Aggarwal, and Ingrid E. Lundberg
91. Overlap Syndromes, 1569 Jonathan Graf
Part 13: Vasculitis
92. Classification and Epidemiology of Systemic Vasculitis, 1584 Rennie L. Rhee and Peter A. Merkel
93. Giant Cell Arteritis, Polymyalgia Rheumatica, and Takayasu’s Arteritis, 1595 David B. Hellmann
94. Anti-neutrophil Cytoplasmic Antibody– Associated Vasculitis, 1617 Sharon A. Chung and Paul A. Monach
95. Polyarteritis Nodosa and Related Disorders, 1634 Raashid Luqmani and Abid Awisat
96. Immune Complex–Mediated Small Vessel Vasculitis, 1649 John H. Stone
97. Primary Angiitis of the Central Nervous System, 1659 Rula A. Hajj-Ali and Carol A. Langford
98. Behçet’s Disease, 1666 Christine S. Ahn, Lindsay C. Strowd, and Joseph L. Jorizzo
Part 14: Crystal-Induced and Inflammasome- Mediated Inflammation
99. Pathogenesis of Inflammasome-Mediated Diseases, 1676 Hal M. Hoffman and Lori Broderick
100. Etiology and Pathogenesis of Hyperuricemia and Gout, 1687 Robert T. Keenan, Michael Toprover, and Michael H. Pillinger
101. Clinical Features and Treatment of Gout, 1710 Nicola Dalbeth
102. Calcium Crystal Disease: Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate, 1732 Robert Terkeltaub
103. Familial Autoinflammatory Syndromes, 1752 Catharina M. Mulders-Manders, Anna Simon, and Jos W.M. van der Meer
Part 15: Cartilage, Bone, and Heritable Connective Tissue Disorders
104. Pathogenesis of Osteoarthritis, 1770 Paul E. Di Cesare, Dominik R. Haudenschild, Steven B. Abramson, and Jonathan Samuels
105. Clinical Features of Osteoarthritis, 1789 Amanda E. Nelson
106. Treatment of Osteoarthritis, 1803 Devyani Misra, Deepak Kumar, and Tuhina Neogi
107. Metabolic Bone Disease, 1819 Nancy E. Lane
108. Proliferative Bone Diseases, 1839 Reuven Mader
109. Osteonecrosis, 1852 Christopher Chang, Adam Greenspan, and M. Eric Gershwin
110. Relapsing Polychondritis, 1876 Gaye Cunnane
111. Heritable Diseases of Connective Tissue, 1886 Deborah Krakow
Part 16: Rheumatic Diseases of Childhood
112. Etiology and Pathogenesis of Juvenile Idiopathic Arthritis, 1905 Edward M. Behrens
113. Clinical Features and Treatment of Juvenile Idiopathic Arthritis, 1911 Joyce J. Hsu, Tzielan C. Lee, and Christy I. Sandborg
114. Childhood-Onset Systemic Lupus Erythematosus, Drug-Induced Lupus in Children, and Neonatal Lupus, 1931 Stacy P. Ardoin and Fatima Barbar-Smiley
115.Juvenile Dermatomyositis, Scleroderma, Vasculitis, and Autoimmune Brain Disease, 1942 Angela B. Robinson, Jeffrey Dvergsten, Kathryn S. Torok, Heather Van Mater, William Gallentine, and Ann M. Reed
Part 17: Infection and Arthritis
116. Bacterial Arthritis, 1979 Paul P. Cook and Dawd S. Siraj
117. Lyme Disease, 1994 Linda K. Bockenstedt
118. Mycobacterial Infections of Bones and Joints, 2009 Eric M. Ruderman and John P. Flaherty
119. Fungal Infections of Bones and Joints, 2022 Eric M. Ruderman and John P. Flaherty
120. Rheumatic Manifestations of HIV Infection, 2033 Jonathan Dau and John D. Reveille
121. Viral Arthritis, 2048 Philippe Gasque and Xavier Guillot
122. Rheumatic Fever and Post-streptococcal Arthritis, 2061 Luiza Guilherme, Pedro Ming Azevedo, and Jorge Kalil
Part 18: Arthritis Accompanying Systemic Disease
123. Amyloidosis, 2077 Helen J. Lachmann and Faye A. Sharpley
124. Sarcoidosis, 2088 Peter Korsten, Nadera J. Sweiss, and Robert P. Baughman
125. Hemochromatosis, 2105 Gaye Cunnane
126. Hemophilic Arthropathy, 2115 Astrid E. Pulles, Lize F. D. van Vulpen, and Floris P.J.G. Lafeber
127. Rheumatic Manifestations of Hemoglobinopathies, 2127 Carlos J. Lozada and Elaine C. Tozman
128. IgG4-Related Disease, 2135 John H. Stone and Shiv Pillai
129. Arthritis Accompanying Endocrine and Metabolic Disorders, 2149 Sebastian E. Sattui and Joseph A. Markenson
130. Rheumatic Paraneoplastic Syndromes—Links Between Malignancy and Autoimmunity, 2161 Bernhard Manger and Georg Schett
131. Tumors and Tumor-like Lesions of Joints and Related Structures, 2167 Darcy A. Kerr and Andrew E. Rosenberg
132. Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer, 2189 Laura C. Cappelli, Clifton O. Bingham III, and Ami A. Shah
Index, I-1
