Description
Through 10 outstanding editions, Kelley & Firestein's Textbook of Rheumatology has provided authoritative, in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. The 11th Edition of this classic text continues this tradition of excellence, while keeping you abreast of recent advances in genetics and the microbiome, new therapies such as biologics and biosimilars, and other rapid changes in the field. It provides comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, in a user-friendly, full color reference.- Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes—including key data on therapeutic outcomes to better inform clinical decision making.- Includes new chapters on Innate Lymphoid Cells and Natural Killer Cells, Pathogenesis of Inflammasome Mediated Diseases, Bisphosphonates, Ultrasound Evaluation of the Musculoskeletal System, and Evaluation of Monoarticular and Polyarticular Arthritis.- Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs.- Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editor Dr. Gary Koretzky, specialist in immunology and rheumatology.- Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints.- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Table of Contents
VOLUME IPart 1: Structure and Function of Bone, Joints, and Connective Tissue1. Biology of the Normal Joint, 1 Carla R. Scanzello and Steven R. Goldring2. Synovium, 20 Douglas J. Veale and Gary S. Firestein3. Cartilage and Chondrocytes, 34 Ali Mobasheri, Mary B. Goldring, and Richard F. Loeser4. Biology, Physiology, and Morphology of Bone, 60 Aline Bozec, Anika Grüneboom, and Georg Schett5. Muscle: Anatomy, Physiology, and Biochemistry, 67 Mark S. Miller, Edward P. Debold, and Michael J. Toth6. Biomechanics, 80 Kenton R. Kaufman and KaiNan An7. Regenerative Medicine and Tissue Engineering, 92 Frank P. Luyten, Cosimo De Bari, and Francesco Dell'Accio8. Proteinases and Matrix Degradation, 109 Yoshifumi ItohPart 2: Cells Involved in Autoimmune Diseases and Inflammation9. Dendritic Cells, 132 Mansi Saxena, Nicolas Vabret, Luciana Ribeiro Muniz, and Nina Bhardwaj10. Mononuclear Phagocytes, 149 Deborah R. Winter, Anna Montgomery, and Harris Perlman11. Neutrophils, 161 Binita Shah, Nathalie Burg, and Michael H. Pillinger12. T Lymphocytes, 182 Ralph C. Budd13. B Cells, 199 Yong-Rui Zou, Christine Grimaldi, and Betty Diamond14. Fibroblasts and Fibroblast-like Synoviocytes, 222 Christopher D. Buckley and Andrew Filer15. Mast Cells, 241 Peter A. Nigrovic16. Innate Lymphoid Cells and Natural Killer Cells, 254 Michael A. Paley and Wayne M. Yokoyama17. Platelets and Megakaryocytes, 262 Eric Boilard and Peter A. NigrovicPart 3: Effector Mechanisms in Autoimmunity and Inflammation18. Principles of Signaling, 273 Abel Suarez-Fueyo, Vaishali R. Moulton, and George C. Tsokos19. The Immunologic Repercussions of Cell Death, 286 Helen M. Beere and Douglas R. Green20. Innate Immunity, 306 Gregoire Lauvau and Steven A. Porcelli21. Adaptive Immunity, 320 Martha S. Jordan and Gary A. Koretzky22. Autoimmunity and Tolerance, 337 Dwight H. Kono and Argyrios N. Theofilopoulos23. The Microbiome in Health and Disease, 355 Rob Knight24. Metabolic Regulation of Immunity, 368 Ruoning Wang, Tingting Wang, and Stephen Tait25. Genetics of Rheumatic Diseases, 378 Stephen Eyre and Anne Barton26. Epigenetics of Rheumatic Diseases, 393 Amr H. Sawalha and Matlock A. Jeffries27. Complement System, 409 V. Michael Holers and Leendert A. Trouw28. Prostaglandins, Leukotrienes, and Related Compounds, 420 Robert B. Zurier29. Chemokines and Cellular Recruitment, 437 Gerard Graham30. Angiogenesis, 445 Ursula Fearon, Zoltán Szekanecz, and Douglas J. Veale31. Cytokines, 455 Iain B. McInnes32. Experimental Models for Rheumatoid Arthritis, 467 Rikard Holmdahl33. Neuronal Regulation of Pain and Inflammation, 480 Camilla I. Svensson and Linda S. SorkinPart 4: Broad Issues in the Approach to Rheumatic Disease34. Clinical Research Methods in Rheumatic Disease, 495 Jeffrey R. Curtis, Yvonne M. Golightly, and Kenneth G. Saag35. Economic Impact of Arthritis and Rheumatic Conditions, 510 Louise B. Murphy36. Assessment of Health Outcomes, 522 Dorcas E. Beaton, Maarten Boers, Peter Tugwell, and Lara Maxwell37. Biomarkers in Rheumatology, 536 Michael J. Townsend, Saloumeh K. Fischer, and Andrew C. Chan38. Occupational and Recreational Musculoskeletal Disorders, 551 Richard S. Panush39. Cardiovascular Risk in Inflammatory Rheumatic Disease, 563 Cynthia S. Crowson, Sherine E. Gabriel, and Anne Grete Semb40. Cancer Risk in Rheumatic Diseases, 579 Eric L. Matteson41. Introduction to Physical Medicine and Rehabilitation, 592 Sara J. Cuccurullo, Jaclyn Joki, and Ofure Luke42. Pregnancy and Rheumatic Diseases, 604 Lisa R. Sammaritano and Bonnie L. BermasPart 5: Evaluation of Generalized and Localized Symptoms43. History and Physical Examination of the Musculoskeletal System, 621 John M. Davis III, Kevin G. Moder, and Gene G. Hunder44. Ultrasound in Rheumatology, 638 Eugene Y. Kissin, Paul J. DeMarco, and Amy C. Cannella45. Evaluation of Monoarticular and Polyarticular Arthritis, 663 Ronald F. van Vollenhoven46.
