Description
Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions.- Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field- Describes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafish- Features examples of zebrafish models of human central nervous system disorders- Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics
Table of Contents
Section I. Introduction to Zebrafish: Natural Habitat, Ethology, and Appropriate Maintenance Conditions1. The biotic and abiotic environment of zebrafish 2. Maintenance and breeding of zebrafish, with some ethological and ecological considerations in mindSection II. The Behavior of the Fry3. The larval visual system and behavioral responses to visual stimuli4. Visual escape in larval zebrafish: Stimuli, circuits, and behavior5. Functional review of hearing in zebrafish6. The development of social behavior7. Classical and operant conditioning in larval zebrafishSection III. The Behavior of the Adult8. Motor patterns and swim path characteristics: the ethogram of zebrafish9. Behavioral criteria and techniques to define sleep in zebrafish10. Fear responses and antipredatory behavior of zebrafish: A translational perspective11. Social behavior and its psychopharmacological and genetic analysis in zebrafish12. Associative and non-associative learning in adult zebrafish13. Relational learning in zebrafish: A model of declarative memory in humans?Section IV. Genetic Methods for Zebrafish14. Molecular genetic approaches to dissect complex behaviors in zebrafish15. Behavioural research in zebrafish (Danio rerio): strain as source of variation16. Designer mutants for behavioral genetics17. Optogenetics18. The CRISPR/Cas system in zebrafish19. PhOTO Zebrafish and primed conversion: Advancing the mechanistic view of development and diseaseSection V. Disease Models and Behavior Genetic Applications20. Acute and chronic alcohol effects in zebrafish21. Behavioural genetics of embryonic ethanol exposure in zebrafish: A model for FASD22. Life, death, and regeneration of zebrafish dopaminergic neurons23. Parkinson's Disease24. Seizures and epilepsy25. Aging, circadian clock and neurogenesis: the zebrafish approach26. Modeling autism spectrum disorders in zebrafish27. Studying aggression in zebrafish28. Methylmercury induces transgenerationally transmissible epigenetic changes influencing zebrafish behaviorSection VI. Big Data and Bioinformatics29. The design of behavioral screening in zebrafish30. Software tools for behavioral phenotyping of zebrafish across the life span31. The Zebrafish Genome Sequencing Project: Bioinformatics resources32. Registered, standardized, and interactive: a review of online resources for zebrafish neuroanatomy
