Description
Alzheimer's disease (AD) and vascular dementia (VaD) are commonly viewed as the first and second most common types of dementia, respectively. The traditional paradigm has been to view and treat each illness as a separate entity with a separate pathophysiology. However, clinical and pathological studies suggest that the boundary separating AD and VaD, as well as their mild cognitive impairment (MCI) analogs, is not well defined. Thus, there is increased interest in viewing these diseases along a spectrum because of the significant overlap in the characterization and diagnosis of AD, VaD, and MCI. The focus of this edited volume is to examine how AD and VaD, as well as their MCI analogs, are best viewed as a heterogeneous, intersecting, if not a continuous disease state rather than separate, distinct entities. This book examines this approach by providing empirically based evidence, reviews of the literature, and chapters by key leaders in the field and will be of interest to clinical neuropsychologists and anyone studying or treating dementia in its many forms.
Table of Contents
PrefacePart 1: Epidemiology and NeuropsychologyChapter 1: Vascular risk factors and their relationship to brain aging: Findings from the Framingham Heart StudyChapter 2: Neuropsychological Profiles in Alzheimer's/ Vascular Spectrum DementiaChapter 3: Neuropsychological Diagnostic Criteria for Mild Cognitive Impairment due to Alzheimer's DiseaseChapter 4: Vascular Cognitive ImpairmentChapter 5: Decline in Everyday Functioning in MCI and Dementia: A Neuropsychological PerspectiveChapter 6: Heterogeneity in Dementia and MCI: Using Statistical Modeling TechniquesChapter 7: Apraxic and Action-Intentional Disorders Associated With Vascular And Degenerative Dementing DiseasesPart 2: NeuroimagingChapter 8: Cerebral small vessel disease and the risk of dementia and cognition declineChapter 9: Structural MRI in Alzheimer's disease: Are we measuring the right stuffChapter 10: Advances in Multi-Modal Imaging Across the Spectrum of Normal to Pathological aging: Incorporating Vascular Comorbidities Common to Alzheimer's disease and Vascular DementiaPart 3: Blood-Brain-Barrier and Cardiogenic MechanismsChapter 11: The Blood-Brain Barrier in Cognitive Decline and Alzheimer's DiseaseChapter 12: Arterial Stiffening and Cerebrovascular Resistance in Cognitive Decline and Alzheimer's DiseaseChapter 13: Hemodynamics in Alzheimer's Disease and Vascular Cognitive Impairment & DementiaPart 4: Neuropathological and Neurophysiological MechanismsChapter 14: Neuropathology of AD/ VaD DementiaChapter 15: Potential of blood- and CSF-based biomarkers for AD diagnosticsChapter 16: Unravelling the Role of Mitochondria in Alzheimer's disease: Toward Assembling the PuzzlePart 5: Treatment and InterventionChapter 17: Dementia and Elective Surgeries: Considerations for NeuropsychologistsChapter 18: Management of Mild Cognitive Impairment
