Description
Recent Advancement in Prodrugs
Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations.
Key features
- Covers recent advancements in development of prodrugs
- Presents balanced synthesis and applications of prodrug chemistry
- Discusses broad spectrum of prodrug categories and outlines industrial applications
- Reviews prodrugs in cancer nanomedicine, its therapy and treatment
- Elucidates mathematical models to study the kinetics of prodrugs
This book covers recent advances in the design of prodrugs. It contains all the significant recent examples of prodrug chemistry developments and will aid academics and researchers seeking to generate new projects in the field.
Table of Contents
Chapter 1: Recent Advancements in New Drug Design and Development of Prodrugs
Kamal Shah, Gourav Krishna, Jeetendra Kumar Gupta, Durgesh Nandini Chauhan, Nagendra Singh Chauhan, and Pradeep Mishra
Chapter 2: Codrugs: Optimum Use through Prodrugs
Suneela Dhaneshwar, Poorva shree Joshi, and Shubham Pawar
Chapter 3: Role of Prodrugs in Drug Design
Asadullah Madni, Sobia Noreen, Afifa Shafique, Abdur Rahim, Muhammad Sarfraz, and
Attia Afzal
Chapter 4: Prodrugs for Enhancement of Lipophilicity
Suneela Dhaneshwar and Neha Bhilare
Chapter 5: Lipidic Prodrugs for Drug Delivery: Opportunities and Challenges
Milica Markovic, Shimon Ben-Shabat, and Arik Dahan
Chapter 6: The Progress of Prodrugs in Drug Solubility
Guilherme Felipe dos Santos Fernandes, Igor Muccilo Prokopczyk, Chung Man Chin, and Jean Leandro dos Santos
Chapter 7: Prodrugs for CNS Drug Delivery
Katalin Prokai-Tatrai
Chapter 8: Prodrugs for Cancer Treatment
W.L. Stone, V. Palau and K. Krishnan
Chapter 9: Prodrugs in Cancer Nanomedicine and Therapy
Vikas Pandey, Tanweer Haider, Vishal Gour, Vandana Soni, and Prem N Gupta
Chapter 10: Nitroreductases in Prodrug Therapies
Tuğba Güngör, Ferah Cömert Önder, and Mehmet Ay
Chapter 11: Prodrug Approach Using Carboxylesterase: Different Substrate Specificities of Human Carboxylesterase Isozymes
M. Takahashi and M. Hosokawa
Chapter 12: Mathematical Models for ADME of Prodrugs
Vipin Bhati, Navyashree V, Shamsher Singh, Pooja Chawla, and Anoop Kumar
Chapter 13: Prodrug Approaches for Natural Products
Sudhir Kumar Thukral, Pooja Chawla, Alok Sharma, and Viney Chawla
Chapter 14: Biotechnology-Based Prodrug Approach for Cell-Specific Targeting: Its Theoretical Basis and Application
Sunita Minz, Manju Rawat Singh, Deependra Singh, Arun Singh Parihar, and Madhulika Pradhan
