Description
Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology.
- Presents our current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli
- Provides a review of diseases with known or purported mechanobiological underpinnings
- Includes the role of mechanobiology in tissue engineering and regenerative medicine
- Covers experimental methods to capture mechanobiological phenomena
Table of Contents
Section 1: Mechanobiological basis of diseases1.1 Osteoporosis1.2 Cardiovascular mechanics and disease1.3 Glaucoma and eye diseases1.4 Growth and development1.5 Tissue engineering and regenerative medicine
Section 2: Cellular basis of Mechanobiology 2.1 Cells as strain gages and load cells2.2 Cell – extracellular matrix interactions2.3 Mechanobiological pathways2.4 Mechanically mediated epigenetics
Section 3: Experimental methods3.1 Effects of shear stress on cells3.2 Three-dimensional culture systems3.3 Bioreactors3.4 Tissue and organ on a chip systems
Section 4: Computational simulations in mechanobiology4.1 Cell aggregation4.2 Growth models5. Future prospects and challenges6. Bibliography7. Glossary
