Description
The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P's" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments.The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment.- Gives a thorough and important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and its therapy- Provides thorough, up-to-date information on specific diseases, along with clinical applications in an easily found reference for clinicians and researchers interested in certain diseases- Keeps readers abreast of current trends and emerging areas in the field- Ensures that content is not only up-to-date, but applicable and relevant- Includes new, updated chapters that emphasize hot topics in the field, e.g., research on auto inflammatory diseases and autoimmune responses following cancer immunotherapy
Table of Contents
Section 1: Immunologic Basis of Autoimmunity1. Prelude: Historical introduction to autoimmunity and autoimmune disease2. Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity3. General Features of Autoimmune Diseases4. Antigen Presentation, Dendritic Cells, and Autoimmunity5. T cells and their subsets6. Role of Th1 Th2 Th17 Cells in Autoimmunity7. Tolerance and Autoimmunity: T Cells8. Regulatory T Cells9. B Cells and Autoimmunity10. Immunological memory T cells11. Immunological memory B cells 12. Apoptotic Cells as a Source of Autoantigens13. Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes14. Functional Effects of Autoantibodies15. Cytokine Chemokines16. Signaling Pathways in T and B Lymphocytes17. HLA Genetics and Autoimmunity18. Non HLA Genetics19. AIRE related Autoimmunity20. Immune Deficiencies and Autoimmunity21. Infections and Autoimmunity22. Noninfectious Environmental Agents and Autoimmunity23. Sex, Pregnancy and Autoimmunity24. Animal Models of Autoimmune DiseaseSection 2: Multisystem Diseases25. Systemic Lupus Erythematosus 26. Systemic Sclerosis, Scleroderma27. Antiphospholipid Syndrome28. Sjogren Syndrome29. Rheumatoid Arthritis30. Spondyloarthritis and Chronic Idiopathic Arthropathies31. Myositis32. Thyroid Disease33. Type 1 Diabetes34. Adrenalitis35. Polyendocrine Syndromes36. Gastritis and Pernicious Anemia37. Hypophysitis38. Hemolytic Anemia39. Thrombocytopenic Purpura40. Neutropenia41. Aplastic Anemia42. Clotting Disorders43. Multiple Sclerosis44. Peripheral Neuropathy45. Myasthenia Gravis46. Ocular Disease47. Inner Ear Disease48. Celiac Disease49. Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn's Disease50. Chronic Hepatitis51. Primary Billiary Cirrhosis52. Primary Sclerosing Cholangitis53. Pancreatitis54. Bullous Skin Diseases: Pemphigus and Pemphigoid55. Non-Bullous Skin Diseases: Alopecia, Vitiligo, Psoriasis and Urticaria56. Kidney Disease: Goodpasture's Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis57. Orchitis and Male Infertility58. Oophoritis59. Rheumatic Heart Disease60. Myocarditis and Dilated Cardiomyopathy61. Necrotizing Arteritis and Small Vessel Vasculitis62. Large and Medium Vessel Vasculitides63. Autoimmune Disorders of the Lung64. Paraneoplastic Diseases65. Antibody-Associated Neurological Diseases66. Autoinflammatory and other Related DiseasesSection 3: Diagnosis, Prevention, and Therapy67. Autoantibody Assays, Testing, and Standardization 68. Prediction of Autoimmune Disease69. Emerging Therapies for Autoimmune Diseases70. Postlude
