Description
Platelets, Fourth Edition, integrates the entire field of platelet biology, pathophysiology, and clinical medicine with contributions from 142 world experts from 18 countries. This award-winning reference provides clear presentations by basic scientists on the cellular, molecular, and genetic mechanisms of platelets and the role of platelets in thrombosis, hemorrhage, inflammation, antimicrobial host defense, wound healing, angiogenesis and cancer. It also provides start-of-the-art presentations by hematologists, cardiologists, stroke physicians, blood bankers, pathologists and other clinicians on platelet function testing, disorders of platelet numbers and function, antiplatelet therapy and therapy to increase platelet numbers and/or function.Since the publication of the Third Edition of Platelets, there has been a rapid expansion of knowledge in both basic biology of platelets and the clinical approach to platelet-related diseases. This Fourth Edition of Platelets draws all this information into a single, comprehensive and authoritative resource.- Comprehensive and definitive source of state-of-the-art knowledge about platelets- Integrates the entire field of platelet biology, pathophysiology, and clinical medicine- Written for clinicians, pathologists and scientists by 142 world-renowned experts from 18 countries- Completely revised and updated, with 11 new chapters on topics such as platelet glycobiology, the platelet transcriptome, platelet inhibitory receptors, platelet function testing in clinical research trials, therapeutic platelet-rich plasma in wound healing, and new antiplatelet drugs- Full color textbook with over 250 illustrations and 15,000 references
Table of Contents
PART I: Platelet Biology1. The Evolution of Mammalian Platelets2. Megakaryocyte Development and Platelet Formation3. The Structure of Resting and Activated Platelets4. Platelet Glycobiology and the Control of Platelet Function and Lifespan5. Platelet Genomics6. Platelet MicroRNAs7. The Platelet Transcriptome in Health and Disease8. The Platelet Proteome9. Platelet Receptors10. The Glycoprotein Ib-IX-V Complex11. GPVI and CLEC-212. Integrin αIIbβ313. Protease-Activated Receptors14. The Platelet P2 Receptors15. Platelet Inhibitory Receptors16. Interactions Between Platelets, Leukocytes, and the Endothelium17. Inhibition of Platelet Function by the Endothelium18. Platelet Signal Transduction19. Platelet Secretion20. Hemostatic Thrombus Formation in Flowing Blood21. Interactions Between Platelets and the Coagulation System22. Platelet-Derived Extracellular Vesicles23. Regulation of Fibrinolysis by Platelets24. The Role of Platelets in Angiogenesis25. Platelet Function in the NewbornPART II: The Role of Platelets in Disease26. The Role of Platelets in Atherothrombosis27. The Role of Platelets in Diabetes Mellitus28. The Role of Platelets in Inflammation29. The Role of Platelets in Antimicrobial Host Defense30. The Role of Platelets in Tumor Growth, Metastasis, and Immune Evasion31. The Role of Platelets in Sickle Cell DiseasePART III: Clinical Tests of Platelet Function32. Platelet Counting33. Clinical Tests of Platelet Function34. Platelet Aggregation35. Flow Cytometry36. Laboratory Monitoring of Antiplatelet Therapy37. Platelet Function Testing in Clinical Research TrialsPART IV: Disorders of Platelet Number and/or Function38. The Clinical Approach to Disorders of Platelet Number and Function39. Immune Thrombocytopenia (ITP)40. Drug-Induced Thrombocytopenia41. Heparin-Induced Thrombocytopenia42. Thrombotic Thrombocytopenic Purpura and Hemolytic-Uremic Syndromes43. Thrombocytopenia in Pregnancy44. Thrombocytopenia in the Newborn45. Alloimmune Thrombocytopenia46. Inherited Thrombocytopenias47. Thrombocytosis and Essential Thrombocythemia48. Inherited Disorders of Platelet Function49. Acquired Disorders of Platelet FunctionPART V: Antiplatelet Therapy50. Aspirin51. P2Y12 Antagonists52. αIIbβ3 (GPIIb-IIIa) Antagonists53. PAR-1 Antagonists54. Phosphodiesterase Inhibitors55. Novel Antiplatelet Therapies56. Antiplatelet Drugs in the Management of Coronary Artery Disease57. Antiplatelet Drugs in the Management of Cerebral Ischemia58. Antiplatelet Drugs in the Management of Thrombotic/Ischemic Events in Peripheral Artery Disease59. Antiplatelet Drugs in the Management of Venous Thromboembolism, Cardioembolism, Ventricular Assist Devices, and Pregnancy Complications60. Antiplatelet Drugs in the Management of Thrombotic/Ischemic Events in ChildrenPART VI: Therapy to Increase Platelet Numbers and/or Function61. Thrombopoietin Receptor Agonists62. Desmopressin (DDAVP)63. Factor VIIa64. Platelet Transfusion Medicine65. Therapeutic Platelet-Rich Plasma in Wound Healing66. Stem Cell-Derived Platelets67. Gene Therapy for Platelet Disorders
