Description
Gain a foundational understanding of cardiovascular physiology and how the cardiovascular system functions in health and disease. Cardiovascular Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner, while helping you bridge the gap between normal function and disease with pathophysiology content throughout the book.- Helps you easily master the material in a systems-based curriculum with learning objectives, Clinical Concept boxes, highlighted key words and concepts, chapter summaries, self-study questions, and a comprehensive exam to help prepare for USMLEs.- Keeps you current with the latest concepts in vascular, molecular, and cellular biology as they apply to cardiovascular function, thanks to molecular commentaries in each chapter.- Includes clear, 2-color diagrams that simplify complex concepts.- Features clinical commentaries that show you how to apply what you've learned to real-life clinical situations. Complete the Mosby Physiology Series! Systems-based and portable, these titles are ideal for integrated programs.- Blaustein, Kao, & Matteson: Cellular Physiology and Neurophysiology- Cloutier: Respiratory Physiology- Koeppen & Stanton: Renal Physiology- Johnson: Gastrointestinal Physiology- White, Harrison, & Mehlmann: Endocrine and Reproductive Physiology- Hudnall: Hematology: A Pathophysiologic Approach- Appendix - Comprehensive MCQ review examination- Keywords/concepts
Table of Contents
Chapter 1 OVERVIEW OF THE CIRCULATION AND BLOODThe Circulatory SystemBloodErythrocytesLeukocytesLymphocytesPlateletsBlood Is Divided into Groups by Antigens Located on ErythrocytesSummaryCase 1-1Chapter 2 EXCITATION: THE CARDIAC ACTION POTENTIALCardiac Action Potentials Consist of Several PhasesThe Principal Types of Cardiac Action Potentials Are the Slow and Fast TypesIonic Basis of the Resting PotentialThe Fast Response Depends Mainly on Voltage-Dependent Sodium ChannelsIonic Basis of the Slow ResponseConduction in Cardiac Fibers Depends on Local Circuit CurrentsConduction of the Fast ResponseConduction of the Slow ResponseCardiac Excitability Depends on the Activation and Inactivation of Specific CurrentsFast ResponseSlow ResponseEffects of Cycle LengthSummaryCase 2-1Chapter 3 AUTOMATICITY: NATURAL EXCITATION OF THE HEARTThe Heart Generates Its Own Pacemaking ActivitySinoatrial NodeIonic Basis of AutomaticityOverdrive SuppressionAtrial ConductionAtrioventricular ConductionVentricular ConductionAn Impulse Can Travel Around a Reentry LoopAfterdepolarizations Lead to Triggered ActivityEarly AfterdepolarizationsDelayed AfterdepolarizationsElectrocardiography Displays the Spread of Cardiac ExcitationScalar ElectrocardiographyDysrhythmias Occur Frequently and Constitute Important Clinical ProblemsAltered Sinoatrial RhythmsAtrioventricular Transmission BlocksPremature DepolarizationsEctopic TachycardiasFibrillationSummaryCase 3-1Chapter 4 THE CARDIAC PUMPThe Microscopic and Gross Structures of the HeartCardiac Muscle (myocardial) Cell MorphologyStructure of the Heart: Atria, Ventricles, and ValvesThe Force of Cardiac Contraction Is Determined by Excitation-Contraction Coupling and the Initial Sarcomere Length of the Myocardial CellsExcitation-Contraction Coupling Is Mediated by CalciumMechanics of Cardiac MuscleThe Sequential Contraction and Relaxation of the Atria and Ventricles Constitute the Cardiac CycleVentricular SystoleEchocardiography Reveals Movement of the Ventricular Walls and of the ValvesThe Two Major Heart Sounds Are Produced Mainly by Closure of the Cardiac ValvesThe Pressure-Volume Relationships in the Intact HeartPassive or Diastolic Pressure-Volume RelationshipActive or End-Systolic Pressure-Volume RelationshipPressure and Volume during the Cardiac Cycle: The P-V LoopPreload and Afterload during the Cardiac CycleContractilityThe Fick Principle Is Used to Determine Cardiac OutputMetabolism of ATP and its Relation to Mechanical FunctionFatty Acid MetabolismCarbohydrate MetabolismInterrelation between Fatty Acid and Carbohydrate MetabolismEffects of plasma substrate and insulin levelsCardiac O2 Consumption and the Link between Ventricular Function and Cardiac MetabolismSummaryCase 4-1Chapter 5 REGULATION OF THE HEARTBEATHeart Rate is Controlled Mainly by the Autonomic NervesParasympathetic PathwaysSympathetic PathwaysHigher Centers Also Influence Cardiac PerformanceHeart Rate Can Be Regulated via the Baroreceptor ReflexThe Bainbridge Reflex and Atrial Receptors Regulate Heart RateRespiration Induces a Common Cardiac DysrhythmiaActivation of the Chemoreceptor Reflex Affects Heart RateVentricular Receptor Reflexes Play a Minor Role in the Regulation of Heart RateMyocardial Performance Is Regulated by Intrinsic MechanismsThe Frank-Starling Mechanism Is an Important Regulator of Myocardial Contraction ForceChanges in Heart Rate Affect Contractile ForceMyocardial Performance Is Regulated by Nervous and Humoral FactorsNervous ControlCardiac Performance Is Also Regulated by Hormonal SubstancesSummaryCase 5-1Chapter 6 HEMODYNAMICSVelocity of the Bloodstream Depends on Blood Flow and Vascular AreaBlood Flow Depends on the Pressure GradientRelationship Between Pressure and Flow Depends on the Characteristics of the ConduitsResistance to FlowResistances in Series and in ParallelFlow May Be Laminar or TurbulentShear Stress on the
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- Introduction to Com…
