Description
Gain a foundational understanding of renal physiology and how the renal system functions in health and disease. Renal Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner, while helping you bridge the gap between normal kidney function and disease with pathophysiology content throughout the book.- Helps you easily master the material in a systems-based curriculum with learning objectives, "In the Clinic" and "At the Molecular Level" boxes, chapter summaries, clinical cases with review questions and answers, self-study questions, and a comprehensive exam.- Includes more than 250 clear, 2-color diagrams that simplify complex concepts.- Features clinical commentaries that show you how to apply what you've learned to real-life clinical situations. Complete the Mosby Physiology Series! Systems-based and portable, these titles are ideal for integrated programs.- Blaustein, Kao, & Matteson: Cellular Physiology and Neurophysiology- Cloutier: Respiratory Physiology- Pappano & Wier: Cardiovascular Physiology- Johnson: Gastrointestinal Physiology- White, Harrison, & Mehlmann: Endocrine and Reproductive Physiology- Hudnall: Hematology: A Pathophysiologic Approach
Table of Contents
INTRODUCTIONCHAPTER 1PHYSIOLOGY OF BODY FLUIDSObjectivesConcept of Steady-State BalancePhysicochemical Properties of Electrolyte SolutionsMolarity and EquivalenceOsmosis and Osmotic PressureOsmolarity and OsmolalityTonicityOncotic PressureSpecific GravityVolumes of Body Fluid CompartmentsComposition of Body Fluid CompartmentsFluid Exchange between Body Fluid CompartmentsCapillary Fluid ExchangeCellular Fluid ExchangeSummaryKey Words and ConceptsSelf-Study ProblemsCHAPTER 2STRUCTURE AND FUNCTION OF THE KIDNEYSObjectivesStructure of the KidneysGross AnatomyUltrastructure of the NephronUltrastructure of the GlomerulusUltrastructure of the Juxtaglomerular ApparatusInnervation of the KidneysSummaryKey Words and ConceptsSelf-Study ProblemsCHAPTER 3GLOMERULAR FILTRATION AND RENAL BLOOD FLOWObjectivesRenal ClearanceGlomerular Filtration RateGlomerular FiltrationDeterminants of Ultrafiltrate CompositionDynamics of UltrafiltrationRenal Blood FlowRegulation of Renal Blood Flow and Glomerular Filtration RateSympathetic NervesAngiotensin IIProstaglandinsNitric OxideEndothelinBradykininAdenosineNatriuretic PeptidesAdenosine TriphosphateGlucocorticoidsHistamineDopamineSummaryKey Words and ConceptsSelf-Study ProblemsCHAPTER 4RENAL TRANSPORT MECHANISMS: NaCl AND WATER ABSORPTION ALONG THE NEPHRONObjectivesGeneral Principles of Membrane TransportGeneral Principles of Transepithelial Solute and Water TransportNaCl, Solute, and Water Reabsorption Along the NephronProximal TubuleHenle's LoopDistal Tubule and Collecting DuctRegulation of NaCl and Water ReabsorptionSummaryKey Words and ConceptsSelf-Study ProblemsCHAPTER 5REGULATION OF BODY FLUID OSMOLALITY: REGULATION OF WATER BALANCEObjectivesArginine VasopressinOsmotic Control of Arginine Vasopressin SecretionHemodynamic Control of Arginine Vasopressin SecretionArginine Vasopressin Actions on the KidneysThirstRenal Mechanisms for Dilution and Concentration of the UrineMedullary InterstitiumVasa Recta FunctionAssessment of Renal Diluting and Concentrating AbilitySummaryKey Words and ConceptsSelf-Study ProblemsCHAPTER 6REGULATION OF EXTRACELLULAR FLUID VOLUME AND NaCl BALANCEObjectivesWhole-Body Na+ BalanceConcept of Effective Circulating VolumeVolume-Sensing SystemsVolume Sensors in the Low-Pressure Cardiopulmonary CircuitVolume Sensors in the High-Pressure Arterial CircuitVolume Sensor SignalsRenal Sympathetic NervesRenin-Angiotensin-Aldosterone SystemNatriuretic PeptidesArginine VasopressinControl of Renal NaCl Excretion During EuvolemiaMechanisms for Maintaining Constant Na+ Delivery to the Distal Tubule in EuvolemiaRegulation of Distal Tubule and Collecting Duct Na+ Reabsorption in EuvolemiaControl of Na+ Excretion with Volume ExpansionControl of Na+ Excretion with Volume ContractionEdemaAlterations in Starling ForcesCapillary Hydrostatic Pressure (Pc)Plasma Oncotic Pressure (πc)Lymphatic ObstructionCapillary PermeabilityRole of the KidneysSummaryKey Words and ConceptsSelf-Study ProblemsCHAPTER 7REGULATION OF POTASSIUM BALANCEObjectivesOverview of K+ HomeostasisRegulation of Plasma [K+]EpinephrineInsulinAldosteroneAlterations of Plasma [K+]Acid-Base BalancePlasma OsmolalityCell LysisExerciseK+ Excretion by the KidneysCellular Mechanisms of K+ Transport by Principal Cells and Intercalated Cells in the Distal Tubule and Collecting DuctRegulation of K+ Secretion by the Distal Tubule and Collecting DuctPlasma [K+]AldosteroneArginine VasopressinFactors that Perturb K+ ExcretionFlow of Tubular FluidAcid-Base BalanceGlucocorticoidsSummaryKey Words and ConceptsSelf-Study ProblemsCHAPTER 8REGULATION OF ACID-BASE BALANCEObjectives Buffer SystemOverview of Acid-Base BalanceRenal Net Acid Excretion Reabsorption Along the NephronRegulation of H+ SecretionFormation of NewResponse to Acid-Base DisordersExtracellular and Intracellular BuffersRespiratory Co
