Description
For more than 50 years, Dubois' Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It's an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes.- Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education.- Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients.- Offers an increased focus on the clinical management of related disorders such as Sjogren's syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS).- Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment.- Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.
Table of Contents
Preface, viiList of Contributors, viiiSECTION 1 What Is Lupus?1 History of Lupus, 12 Definition and Classification of Lupus and Lupus-RelatedDisorders, 153 The Epidemiology of Lupus, 23SECTION 2 Pathogenesis4 Overview of Lupus Pathogenesis, 445 Genetics of Human SLE, 546 Epigenetics of Lupus, 697 The Environment and the Host, 868 The Innate Immune System in SLE, 939 B Cells and Generation of Antibodies, 10110 T Cells, 11611 Adaptive and Innate Immunoregulatory Cells, 12512 Cytokines in Lupus, 13713 Immunometabolism, 15314 Animal Models in Lupus, 164SECTION 3 Mechanisms of Tissue Injury15 Abnormalities in Immune Complex Clearance andApoptotic Cell Clearance, 21616 The Role of Complement in SLE, 22417 Apoptosis and Inflammatory Forms of Cell Death, 23718 Tissue Damage in Lupus: Free Radicals and Fibrosis, 24819 Pathogenesis of Fibrosis—The Lung as a Model, 26120 Pathogenesis of Lupus Nephritis, 26921 Pathogenesis of Accelerated Atherosclerosis andVascular Injury in Systemic Lupus Erythematosus, 29422 Pathogenesis of Cutaneous Lupus, 30523 Pathogenesis of Neuropsychiatric Lupus, 31724 Pathogenesis of Antiphospholipid AntibodySyndrome, 32425 Pathogenesis of Sjögren's, 338SECTION 4 Autoantibodies26 Structure and Derivation of Autoantibodies, 34027 Antinuclear Antibodies, Antibodies to DNA, Histones, and Nucleosomes, 35528 Antibodies Against ENA (Sm, RNP, SSA, SSB), 36629 Antibodies Against C1q, 37230 Antilipoprotein and Antiendothelial CellAntibodies, 37531 Drug-Induced Lupus Erythematosus, 377SECTION 5 Clinical Aspects of LupusErythematosus32 Overview and Clinical Presentation, 38933 Skin Disease in Cutaneous Lupus Erythematosus, 39534 The Musculoskeletal System and BoneMetabolism, 40735 Lupus and the Cardiopulmonary System, 41836 Lupus and the Nervous System: Clinical Aspects, Psychopathology, and Imaging, 43437 Gastrointestinal and Hepatic Systems, 45738 Hematologic and Lymphoid Abnormalities in SLE, 47339 Neonatal Lupus: Pathogenesis and ClinicalApproaches, 48640 Pregnancy and Autoimmune Disease, Reproductive andHormonal Issues, 49941 Systemic Lupus Erythematosus in Childhood andAdolescence, 52042 Clinical Aspects of Antiphospholipid Syndrome, 53243 Lupus and Infections, 54344 Ocular, Aural, and Oral Manifestations of Lupus, 55645 Clinical Aspects of Sjögren's, 566SECTION 6 Assessment of Lupus46 Clinical Application of Serologic Tests, Serum ProteinAbnormalities, and Other Clinical Laboratory Tests inSystemic Lupus Erythematosus, 57947 Differential Diagnosis and Disease Associations, 59848 Incomplete Lupus, Undifferentiated Connective TissueDisease, and Mixed Connective Tissue Disease, 60649 Clinical Markers, Metrics, Indices, and ClinicalTrials, 61450 Lupus Biomarkers, 631SECTION 7 Management of Lupus51 Principles of Therapy, Local Measures, and NSAIDs, 64052 Antimalarial Medications, 65053 Systemic Glucocorticoid Therapy for SLE, 66154 Immunosuppressive Drug Therapy, 67355 Complementary and Alternative Medications, Specialized and Niche Therapies, 68956 Adjunctive Treatments and Preventive Measures, 70257 Targeted Therapies in SLE, 71058 Management of Cutaneous Lupus Erythematosus, 71959 Epidemiology and Management of Lupus Nephritis, 72760 Management of Sjögren's, 745SECTION 8 Outcomes61 Socioeconomic and Disability Aspects, 75962 Prognosis and Mortality of SLE, 770Index, 782
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