Description
* Offers a conceptual explanation of the interrelationships that exist between the stages in the progression of initiated epithelial cells in culture compared with the diverse tissue of organs and the
progression of tumors from different organ sites]
* Examines in vitro cellular aging and the role of immortalization
* Presents stages of control of expression and the factors influencing growth and differentiation
Table of Contents
In Vitro Cellular Aging and Immortalization. Detection of Growth Factor Effects and Expression in Normal and Neoplastic Human Bronchial Epithelial Cells. Human Cell Metabolism and DNA Adduction of Polycyclic Aromatic Hydrocarbons. Human Esophageal Epithelial Cells: Immortalization and In Vitro Transformation. Transformation of Human Endometrial Stromal Cells In Vitro. Factors Influencing Growth and Differentiation of Normal and Transformed Human Mammary Epithelial Cells in Culture. Transformation of Colon Epithelial Cells. Multistep Carcinogenesis and Human Epithelial Cells. Morphologic and Molecular Characterizations of Plastic Tumor Cell Phenotypes. Oncogene and Tumor Suppressor Gene Involvement in Human Lung Carcinogenesis. Events of Tumor Progression Associated with Carcinogen Treatment of Epithelial and Fibroblast Compared with Mutagenic Events. Progression from Pigment Cell Patterns to Melanomas in Platyfish-Swordtail Hybrids-Multiple Genetic Changes and a Theme for Tumorigenesis
