Drug Repositioning : Approaches and Applications for Neurotherapeutics

著者名：Dudley, Joel (EDT)/Berliocchi, Laura (EDT)

CRC Press（2017/07/14発売）

• 言語：ENG
• ISBN：9780367869076
• eISBN：9781315356211

Description

Nervous system diseases represent a major health concern worldwide. Although important financial and professional investment, their etiology and pathophysiology still remain mostly elusive. Moreover, the clinical need of disease-modifying therapies is still unmet.

In the last decades, traditional R&D has failed in identifying new effective therapies in many medical areas and drug repositioning has recently emerged as a promising alternative strategy to de novo drug discovery to improve and accelerate therapeutic development.

For the first time, Drug Repositioning: Approaches and Applications for Neurotherapeutics reviews history and advances in drug repositioning, with a special focus on therapeutics for nervous system diseases. International experts from Academia, Industry and Non-profit organisations will provide different views on drug repositioning advantages, challenges and specific applications, which will be covered for nervous system diseases including Alzheimer's, Parkinson's, Huntington's diseases, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, ischemic stroke, and psychiatric disorders.

This book provides a balanced overview and synthesis of drug repositioning concept, methods and applications for neurotherapeutics. It represents a valuable resource for students, scientists and clinicians working in academic settings, industry and government agencies within the fields of neuroscience, pharmacology, neurology, pharmaceutical sciences, drug discovery and development.

Table of Contents

Section I The Rationale and Economics

of Drug Repositioning

Chapter 1 Scientific and Commercial Value of Drug Repurposing

David Cavalla

Chapter 2 Repurposing for Alzheimer’s and Parkinson’s Diseases: The

Ideas, the Pipeline, the Successes, and the Disappointments

Hermann Mucke

Chapter 3 Contribution of Not-for-Profit Organizations to Drug Repurposing

Bruce Bloom

Section II Repositioning Approaches and

Technologies: From Serendipity to

Systematic and Rational Strategies

Chapter 4 Systematic Drug Repositioning

Spyros N. Deftereos, Aris Persidis, Andreas Persidis,

Eftychia Lekka, Christos Andronis, and Vassilis Virvillis

Chapter 5 Technical Tools for Computational Drug Repositioning

Francesco Napolitano

Chapter 6 RNAi Screening toward Therapeutic Drug Repurposing

Nichole Orr-Burks, Byoung-Shik Shim, Olivia Perwitasari,

and Ralph A. Tripp

Chapter 7 Phenotypic Screening

Christine M. Macolino-Kane, John R. Ciallella,

Christopher A. Lipinski, and Andrew G. Reaume

Section III Drug Repositioning for

Nervous System Diseases

Chapter 8 A Case Study: Chlorpromazine

Francisco López-Munoz, Cecilio Álamo,

and Silvia E. García-Ramos

Chapter 9 Drug Repurposing for Central Nervous System Disorders: A

Pillar of New Drug Discovery

Mondher Toumi, Aleksandra Caban, Anna Kapuśniak,

Szymon Jarosławski, and Cecile Rémuzat

Chapter 10 Repurposing Opportunities for Parkinson’s Disease Therapies

Giulia Ambrosi, Silvia Cerri, and Fabio Blandini

Chapter 11 Drug Candidates for Repositioning in Alzheimer’s Disease

Maria P. del Castillo-Frias and Andrew J. Doig

Chapter 12 Promising Candidates for Drug Repurposing in Huntington’s

Disease

Francesca Romana Fusco and Emanuela Paldino

Chapter 13 Drug Repositioning Opportunities in Psychiatry

Alexander W. Charney, Joseph R. Scarpa, Douglas M. Ruderfer,

and Dennis S. Charney

Chapter 14 Pharmacology of Amyotrophic Lateral Sclerosis: Old Strategies

and New Perspectives

Tiziana Petrozziello, Valentina Tedeschi, Alba Esposito,

and Agnese Secondo

Chapter 15 Repositioning Clinic-Ready Compounds for the Treatment

of Spinal Muscular Atrophy

Faraz Farooq

Chapter 16 Rescuing Ischemic Brain Injury by Targeting the Immune

Response through Repositioned Drugs

Diana Amantea and Giacinto Bagetta