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Description
This comprehensive volume on the blood-gas barrier (BGB) among vertebrates covers its structure and composition along with aspects of evolution, bioengineering, and morphometry. The book also discusses the embryological development of the BGB, including chronology of events and molecular control in vertebrates; modulation of the barrier function, including cyclic stretch-induced increases in alveolar epithelial permeability; mechanisms of lung vascular/epithelial permeability; transport mechanisms of the BGB, including sodium transport channels; factors affecting trans-barrier traffic of fluids, such as chronic elevation of pulmonary microvascular pressure; stress failure; regulation and repair in acute lung injury; chronic lung disease; and lung transportation.
Ten authoritative chapters approach the blood-gas barrier holistically, from basic structure and development to pathology and treatment. Properties of the BGB are discussed in the earlier chapters, followed by prenatal and post-natal development and mechanisms of the healthy BGB. The latter half of the book delves into the pathology of the BGB, analyzing common afflictions and exploring options for treatment, including its alterations during lung transplantation. Intuitively structured and comprehensive, The Vertebrate Blood-Gas Barrier in Health and Disease is ideal for researchers and clinicians interested in pneumology and angiology.
Table of Contents
Chapter 1 Generalities of gas diffusion applied to the vertebrate blood-gas barriers.- Chapter 2 Morphological and morphometric properties of the blood-gas barrier: comparative perspectives.- Chapter 3 Prenatal and postnatal development of the vertebrate blood-gas barrier.- Chapter 4 Molecular mechanisms regulating the pulmonary blood-gas barrier (BGB).- Chapter 5 Barrier enhancing signals.- Chapter 6 Trans-barrier ion and fluid transport.- Chapter 7 Stress failure of the pulmonary blood-gas barrier.- Chapter 8 The lung endothelial barrier in acute inflammation.- Chapter 9 Lung transplantation and the blood-gas-barrier.- Chapter 10 Stereological studies on transient gas-exchangers, with emphasis on the structure and function of the human placenta in normal and compromised pregnancies.
